Document Detail


HU-331: a cannabinoid quinone, with uncommon cytotoxic properties and low toxicity.
MedLine Citation:
PMID:  17714026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The oxidation of cannabis constituents has given rise to their corresponding quinones, which have been identified as cytotoxic agents. Out of these molecules the quinone of cannabidiol--the most abundant non-psychoactive cannabinoid in Cannabis sativa--has shown the highest cytotoxicity. This compound was named HU-331 and it exerts antiangiogenic properties, induces apoptosis to endothelial cells and inhibits topoisomerase II in nanomolar concentrations. Unlike other quinones, it is not cardiotoxic and does not induce the formation of free radicals. A comparative in vivo study in mice has shown HU-331 to be less toxic and more effective than the commonly used doxorubicin. This review summarises the properties of HU-331 and compares it with doxorubicin and other topoisomerase II inhibitors.
Authors:
Maximilian Peters; Natalya M Kogan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  16     ISSN:  1744-7658     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-23     Completed Date:  2007-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  1405-13     Citation Subset:  IM    
Affiliation:
The Hebrew University, Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Jerusalem, Israel.
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inhibitors / adverse effects,  pharmacology
Animals
Cannabidiol / adverse effects,  analogs & derivatives*,  chemistry,  pharmacology
Cannabinoids / chemistry,  pharmacology*
Cell Death / drug effects,  physiology
Cytotoxins / adverse effects,  chemistry,  pharmacology*
Humans
Quinones / chemistry,  pharmacology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Cannabinoids; 0/Cytotoxins; 0/Quinones; 137252-25-6/cannabidiol hydroxyquinone; 13956-29-1/Cannabidiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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