| The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome. | |
| | |
MedLine Citation:
|
PMID: 21420406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: 5-Hydroxytryptamine (5-HT)3 receptor (5-HT3R) antagonists are effective in treating patients with irritable bowel syndrome (IBS) and have anxiolytic effects. Their therapeutic effects are related, in part, to reducing amygdala engagement during expected visceral pain. A single nucleotide polymorphism in HTR3A, c.-42C>T;(C178T; rs1062613), is associated with altered reactivity of the amygdala during emotional face processing in healthy subjects (controls). We evaluated the influence of this single nucleotide polymorphism on amygdala reactivity to emotional faces and nonemotional stimuli in female patients with IBS and controls. METHODS: We measured brain responses during an affect-matching paradigm in 54 women (26 with IBS, 29 controls) using functional magnetic resonance imaging. We examined associations between HTR3A c.-42C>T genotype (C/C vs T carrier) and responses in amygdala and other regions of brain that expressed high levels of 5-HT3R. RESULTS: The C/C genotype was associated with greater anxiety symptoms in patients with IBS and controls and increased activation of the amygdala under emotional and nonemotional conditions. Among patients with IBS, C/C genotype was associated with greater symptom ratings. A subset of IBS patients with the C/C genotype had increased amygdala responses to nonemotional stimuli, compared with other subjects with C/C genotype. CONCLUSIONS: Regardless of diagnosis, the C/C genotype of the c.-42C>T polymorphism in HTR3A, compared with T carrier status, is associated with increased anxiety and amygdala responsiveness during emotional and nonemotional tasks. This polymorphism was associated with severity of IBS symptoms. Although this genotype is not sufficient for diagnosis of IBS, it is associated with severity of symptoms. |
| | |
Authors:
|
Lisa A Kilpatrick; Jennifer S Labus; Kristen Coveleskie; Christian Hammer; Gudrun Rappold; Kirsten Tillisch; Joshua A Bueller; Brandall Suyenobu; Johana M Jarcho; Jim A McRoberts; Beate Niesler; Emeran A Mayer |
Related Documents
:
|
9246286 - Electroretinographic findings in fuchs' heterochromic cyclitis. 3402626 - Grid photocoagulation improves reading ability in diffuse diabetic macular oedema. 9860406 - Retinal complications and plasma c5a levels during interferon alpha therapy for chronic... 10873996 - Long term changes in the visual fields of patients with temporal lobe epilepsy using vi... 7455626 - Pigmented villonodular synovitis. a follow-up study. 7292376 - Time course of response to prednisolone in chronic airflow obstruction. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-03-21 |
Journal Detail:
|
Title: Gastroenterology Volume: 140 ISSN: 1528-0012 ISO Abbreviation: Gastroenterology Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-06-06 Completed Date: 2011-08-09 Revised Date: 2012-02-16 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: United States |
Other Details:
|
Languages: eng Pagination: 1943-51 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA. lisa@lisakilpatrick.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Amygdala / metabolism, physiopathology* Anxiety / genetics, physiopathology Brain Mapping / methods Case-Control Studies Emotions* Facial Expression* Female Genetic Predisposition to Disease Humans Irritable Bowel Syndrome / diagnosis, genetics*, metabolism, physiopathology Los Angeles Magnetic Resonance Imaging Neuropsychological Tests Phenotype Polymorphism, Single Nucleotide* Receptors, Serotonin, 5-HT3 / genetics*, metabolism Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
|
AT 002681/AT/NCCAM NIH HHS; DK 48351/DK/NIDDK NIH HHS; DK 64539/DK/NIDDK NIH HHS; P50 DK064539-01/DK/NIDDK NIH HHS; R01 DK048351-04/DK/NIDDK NIH HHS; R01 DK048351-14/DK/NIDDK NIH HHS; R24 AT002681-01/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/HTR3A protein, human; 0/Receptors, Serotonin, 5-HT3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The binding of 14-3-3? to membranes studied by intrinsic fluorescence spectroscopy.
Next Document: Aerodigestive Reflexes Protect Against Aspiration in Subjects with Impaired and Preserved Reflexes.