Document Detail


HTLV-I proviral load correlates with progression of motor disability in HAM/TSP: analysis of 239 HAM/TSP patients including 64 patients followed up for 10 years.
MedLine Citation:
PMID:  11517397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To clarify clinical and laboratory findings that may be related to the pathomechanism of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed these findings in 239 patients with HAM/TSP, including 64 patients followed up for 10 years after their first examinations, with special interest in the HTLV-I proviral load in peripheral blood mononuclear cells (PBMCs). The proviral load in PBMCs did not differ in terms of modes of HTLV-I transmission. However, the proviral load in patients with age of disease onset greater than 65 years tended to be higher than those with a younger age of onset. In the 64 patients followed up for 10 years, the clinical symptoms deteriorated in 36 patients (56%), unchanged in 26 patients (41%), and improved in 2 patients (3%). HTLV-I proviral load also appeared to be related to the deterioration of motor disability in these patients. To our knowledge, the present study is the first longitudinal study concerning the relationship between the clinical course of HAM/TSP and HTLV-I proviral load. It is suggested that HTLV-I proviral load is related to the progression of motor disability and is an important factor to predict prognosis of patients with HAM/TSP.
Authors:
T Matsuzaki; M Nakagawa; M Nagai; K Usuku; I Higuchi; K Arimura; H Kubota; S Izumo; S Akiba; M Osame
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurovirology     Volume:  7     ISSN:  1355-0284     ISO Abbreviation:  J. Neurovirol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-08-22     Completed Date:  2001-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508123     Medline TA:  J Neurovirol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  228-34     Citation Subset:  IM    
Affiliation:
Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima City, Kagoshima, Japan.
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MeSH Terms
Descriptor/Qualifier:
Age of Onset
Aged
Disability Evaluation
Disease Progression
Female
Follow-Up Studies
Gait Disorders, Neurologic / epidemiology,  virology
Human T-lymphotropic virus 1*
Humans
Longitudinal Studies
Male
Middle Aged
Neuritis / epidemiology,  virology*
Paraparesis, Tropical Spastic / epidemiology*,  transmission,  virology*
Retrospective Studies
Viral Load*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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