| HTLV-I proviral load correlates with progression of motor disability in HAM/TSP: analysis of 239 HAM/TSP patients including 64 patients followed up for 10 years. | |
| | |
MedLine Citation:
|
PMID: 11517397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To clarify clinical and laboratory findings that may be related to the pathomechanism of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed these findings in 239 patients with HAM/TSP, including 64 patients followed up for 10 years after their first examinations, with special interest in the HTLV-I proviral load in peripheral blood mononuclear cells (PBMCs). The proviral load in PBMCs did not differ in terms of modes of HTLV-I transmission. However, the proviral load in patients with age of disease onset greater than 65 years tended to be higher than those with a younger age of onset. In the 64 patients followed up for 10 years, the clinical symptoms deteriorated in 36 patients (56%), unchanged in 26 patients (41%), and improved in 2 patients (3%). HTLV-I proviral load also appeared to be related to the deterioration of motor disability in these patients. To our knowledge, the present study is the first longitudinal study concerning the relationship between the clinical course of HAM/TSP and HTLV-I proviral load. It is suggested that HTLV-I proviral load is related to the progression of motor disability and is an important factor to predict prognosis of patients with HAM/TSP. |
| | |
Authors:
|
T Matsuzaki; M Nakagawa; M Nagai; K Usuku; I Higuchi; K Arimura; H Kubota; S Izumo; S Akiba; M Osame |
Related Documents
:
|
18810237 - Spinal cord infarction in chinese patients. clinical features, risk factors, imaging an... 4027907 - Myelography for staging medulloblastoma. 16889147 - Tuberculous spondylitis: abscess drainage after failure of anti-tuberculous therapy. 8416347 - Relationship between acquired spastic talipes equinovarus and dystonia musculorum defor... 1374637 - Peroral pharyngeal block for placement of esophageal endoprostheses. 15364687 - European study on intravenous immunoglobulin in multiple sclerosis: results of magnetiz... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of neurovirology Volume: 7 ISSN: 1355-0284 ISO Abbreviation: J. Neurovirol. Publication Date: 2001 Jun |
Date Detail:
|
Created Date: 2001-08-22 Completed Date: 2001-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9508123 Medline TA: J Neurovirol Country: United States |
Other Details:
|
Languages: eng Pagination: 228-34 Citation Subset: IM |
Affiliation:
|
Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima City, Kagoshima, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age of Onset Aged Disability Evaluation Disease Progression Female Follow-Up Studies Gait Disorders, Neurologic / epidemiology, virology Human T-lymphotropic virus 1* Humans Longitudinal Studies Male Middle Aged Neuritis / epidemiology, virology* Paraparesis, Tropical Spastic / epidemiology*, transmission, virology* Retrospective Studies Viral Load* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Viruses can silently prime for and trigger central nervous system autoimmune disease.
Next Document: HIV-1 LTR C/EBP binding site sequence configurations preferentially encountered in brain lead to enh...