| HTLV-I associated and non-associated primary T-cell lymphoma of gastrointestinal tract. | |
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MedLine Citation:
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PMID: 8348075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gastrointestinal (GI) tract is the common extranodal site for non-Hodgkin's lymphoma (NHL), and primary lymphoma of GI tract are mostly of B-cell origin. We have treated 16 patients with primary lymphoma of GI tract between 1981 and 1991, of whom 10 (62%) were of B-cell origin, while 6 (38%) were of T-cell origin. The incidence of T-cell phenotype in our hospital was considered to be much higher than that of previous reports and these 6 patients with primary T-cell lymphoma of GI tract were carefully studied. The primary sites were stomach in 4, ileocecum in 1, and duodenum in 1 case. Their T-cell nature was confirmed by immunohistochemical methods. All were peripheral T-cell lymphomas; one was CD 3+ 4- 8- and the other 5 were CD 3+ 4+ 8-. The antibody against human T-cell leukemia virus type I (HTLV-I) was positive in 3 cases (HTLV-I associated), but negative in 3 (HTLV-I non-associated). The integration of HTLV-I proviral DNA in HTLV-I associated patients was demonstrated by Southern blot analysis after DNA amplification by means of polymerase chain reaction (PCR). The clinical features of the HTLV-I associated and HTLV-I non-associated primary T-cell lymphoma of the GI tract were quite different. HTLV-I associated patients showed leukemic manifestations and tumor involvement of the skin at a later stage of the disease. These observations indicated that HTLV-I can play an important role in the occurrence of primary T-cell lymphoma of GI tract. |
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Authors:
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T Tokioka; Y Shimamoto; O Tokunaga; M Yamaguchi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 9 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-09-15 Completed Date: 1993-09-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 399-405 Citation Subset: IM; X |
Affiliation:
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Department of Internal Medicine, Saga Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blotting, Southern DNA, Neoplasm / analysis DNA, Viral / analysis Digestive System / pathology Female Gastrointestinal Neoplasms / epidemiology, microbiology, pathology* HTLV-I Antibodies / immunology Human T-lymphotropic virus 1 / immunology, isolation & purification Humans Incidence Japan / epidemiology Leukemia-Lymphoma, Adult T-Cell / epidemiology, microbiology, pathology* Leukemic Infiltration Lymphoma, T-Cell / epidemiology, pathology* Male Middle Aged Polymerase Chain Reaction Proviruses / isolation & purification Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/DNA, Viral; 0/HTLV-I Antibodies; 0/Tumor Markers, Biological |
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