Document Detail

HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax.
MedLine Citation:
PMID:  19195675     Owner:  NLM     Status:  MEDLINE    
HTLV-1 is more pathogenic than HTLV-2B. The difference is generally attributed to the properties of their individual transactivating Tax proteins. By using internal Flag-6His tagged Tax-1 and Tax-2B, which display transcriptional activities comparable to the untagged proteins and can be recognized by a single anti-Flag antibody, we demonstrate that Tax-2B is modified by ubiquitination and sumoylation. In addition, Tax2B is distributed in punctuate nuclear structures that include the RelA subunit of NF-kappaB, as has been previously demonstrated for Tax-1.
Marco Turci; Julie Lodewick; Paola Righi; Angela Polania; Maria Grazia Romanelli; Françoise Bex; Umberto Bertazzoni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-04
Journal Detail:
Title:  Virology     Volume:  386     ISSN:  1096-0341     ISO Abbreviation:  Virology     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-16     Completed Date:  2009-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6-11     Citation Subset:  IM    
Department of Mother and Child, Biology and Genetics, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, I-37134 Verona, Italy.
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MeSH Terms
Cell Line
Cell Nucleus / chemistry
Gene Products, tax / metabolism*
Human T-lymphotropic virus 2 / physiology*
Transcription Factor RelA / metabolism
Reg. No./Substance:
0/Gene Products, tax; 0/RELA protein, human; 0/Transcription Factor RelA; 0/tax protein, Human T-lymphotrophic virus 2

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