| HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax. | |
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MedLine Citation:
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PMID: 19195675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HTLV-1 is more pathogenic than HTLV-2B. The difference is generally attributed to the properties of their individual transactivating Tax proteins. By using internal Flag-6His tagged Tax-1 and Tax-2B, which display transcriptional activities comparable to the untagged proteins and can be recognized by a single anti-Flag antibody, we demonstrate that Tax-2B is modified by ubiquitination and sumoylation. In addition, Tax2B is distributed in punctuate nuclear structures that include the RelA subunit of NF-kappaB, as has been previously demonstrated for Tax-1. |
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Authors:
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Marco Turci; Julie Lodewick; Paola Righi; Angela Polania; Maria Grazia Romanelli; Françoise Bex; Umberto Bertazzoni |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-04 |
Journal Detail:
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Title: Virology Volume: 386 ISSN: 1096-0341 ISO Abbreviation: Virology Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-16 Completed Date: 2009-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0110674 Medline TA: Virology Country: United States |
Other Details:
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Languages: eng Pagination: 6-11 Citation Subset: IM |
Affiliation:
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Department of Mother and Child, Biology and Genetics, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, I-37134 Verona, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Cell Nucleus / chemistry Gene Products, tax / metabolism* Human T-lymphotropic virus 2 / physiology* Humans Transcription Factor RelA / metabolism Ubiquitination |
| Chemical | |
Reg. No./Substance:
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0/Gene Products, tax; 0/RELA protein, human; 0/Transcription Factor RelA; 0/tax protein, Human T-lymphotrophic virus 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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