| HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches. | |
| | |
MedLine Citation:
|
PMID: 18421579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A universal cellular defense mechanism against viral invasion is the elimination of infected cells through apoptotic cell death. To counteract host defenses many viruses have evolved complex apoptosis evasion strategies. The oncogenic human retrovirus HTLV-1 is the etiological agent of adult-T-cell leukemia/lymphoma (ATLL) and the neurodegenerative disease known as HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The poor prognosis in HTLV-1-induced ATLL is linked to the resistance of neoplastic T cells against conventional therapies and the immuno-compromised state of patients. Nevertheless, several studies have shown that the apoptotic pathway is largely intact and can be reactivated in ATLL tumor cells to induce specific killing. A better understanding of the molecular mechanisms employed by HTLV-1 to counteract cellular death pathways remains an important challenge for future therapies and the treatment of HTLV-1-associated diseases. |
| | |
Authors:
|
John M Taylor; Christophe Nicot |
Related Documents
:
|
17127399 - Cell dynamics and immune response to blv infection: a unifying model. 1319169 - The role of bovine intraepithelial leukocyte-mediated cytotoxicity in enteric antiviral... 9445079 - Protective immune response to foot-and-mouth disease virus with vp1 expressed in transg... 15791949 - Mechanisms of apoptosis during reovirus infection. 9561909 - An update on clonality, cytokines, and viral etiology in langerhans cell histiocytosis. 17043099 - Human oviductal epithelial cells express toll-like receptor 3 and respond to double-str... 20888269 - Microrna-155 promotes autoimmune inflammation by enhancing inflammatory t cell developm... 3010809 - Cellular resistance to protozoal infection. 22997489 - Arachidonic acid derivatives and their role in peripheral nerve degeneration and regene... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Apoptosis : an international journal on programmed cell death Volume: 13 ISSN: 1573-675X ISO Abbreviation: Apoptosis Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-05-16 Completed Date: 2008-07-09 Revised Date: 2012-03-20 |
Medline Journal Info:
|
Nlm Unique ID: 9712129 Medline TA: Apoptosis Country: United States |
Other Details:
|
Languages: eng Pagination: 733-47 Citation Subset: IM |
Affiliation:
|
Department of Microbiology, Immunology, and Molecular Genetics, University of Kansas Medical Center, 3025 Wahl Hall West, 3901 Rainbow Blvd., Kansas City, KS 66160, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Apoptosis
/
drug effects,
physiology* Cell Transformation, Viral / physiology* Gene Products, tax / physiology Human T-lymphotropic virus 1 / drug effects, physiology* Humans I-kappa B Kinase / physiology Janus Kinases / physiology Leukemia-Lymphoma, Adult T-Cell / drug therapy*, virology* NF-kappa B / antagonists & inhibitors, physiology Paraparesis, Tropical Spastic / drug therapy, virology Proto-Oncogene Proteins c-akt / physiology Receptors, Interleukin-2 / physiology Retroviridae Proteins / physiology STAT Transcription Factors / physiology Tretinoin / pharmacology Tumor Suppressor Protein p53 / physiology Viral Regulatory and Accessory Proteins / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
CA106258/CA/NCI NIH HHS; CA115398/CA/NCI NIH HHS; R01 CA106258-05/CA/NCI NIH HHS; R01 CA106258-08/CA/NCI NIH HHS; R01 CA115398-01A2/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Gene Products, tax; 0/NF-kappa B; 0/Receptors, Interleukin-2; 0/Retroviridae Proteins; 0/STAT Transcription Factors; 0/Tumor Suppressor Protein p53; 0/Viral Regulatory and Accessory Proteins; 0/p12I protein, Human T-lymphotropic virus 1; 0/rof protein, Human T-lymphotropic virus 1; 0/tof protein, Human T-lymphotropic virus 1; 302-79-4/Tretinoin; EC 2.7.10.2/Janus Kinases; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.10/I-kappa B Kinase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Death receptor-4 (DR4) expression is regulated by transcription factor NF-kappaB in response to etop...
Next Document: Androgen deficiency: effects on body composition.