Document Detail


HTLV-1 Tax and adult T-cell leukemia.
MedLine Citation:
PMID:  17127397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human T-lymphotropic virus type I (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 viral transactivator/oncoprotein, Tax, activates viral transcription and usurps regulatory mechanisms that are critical for cell growth and division to facilitate viral replication. The effects that Tax exerts on cells include potent NF-k B activation, cell cycle perturbation and cell transformation. How Tax influences ATL development is incompletely understood at present. While Tax-expression is needed at the early stages of cellular transformation, at later times most ATL cells do not express tax; therefore, genetic and epigenetic changes in HTLV-1-infected cells are believed to play an important role in the etiology of ATL. This review attempts to integrate recent literature on the biological activities of Tax and the properties of HTLV-1 transformed T-cells and ATL cells, and speculate on what cellular changes may collaborate with Tax to effect cell transformation and ATL development.
Authors:
Chou-Zen Giam; Kuan-Teh Jeang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review     Date:  2007-01-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  12     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2007  
Date Detail:
Created Date:  2006-11-27     Completed Date:  2007-08-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1496-507     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA. cgiam@usuhs.mil
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MeSH Terms
Descriptor/Qualifier:
Adult
Cell Transformation, Viral
Gene Products, tax / metabolism*
HTLV-I Infections / metabolism,  virology
Human T-lymphotropic virus 1 / pathogenicity*
Humans
Leukemia-Lymphoma, Adult T-Cell / virology*
NF-kappa B / metabolism
T-Lymphocytes / virology
Grant Support
ID/Acronym/Agency:
R01CA115884/CA/NCI NIH HHS; R01CA75688/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Gene Products, tax; 0/NF-kappa B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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