Document Detail

HSV as a vector in vaccine development and gene therapy.
MedLine Citation:
PMID:  20047039     Owner:  NLM     Status:  MEDLINE    
The very deep knowledge acquired on the genetics and molecular biology of herpes simplex virus (HSV), major human pathogen whose lifestyle is based on a long-term dual interaction with the infected host characterized by the existence of lytic and latent infections, has allowed the development of potential vectors for several applications in human healthcare. These include delivery and expression of human genes to cells of the nervous system, selective destruction of cancer cells, prophylaxis against infection with HSV or other infectious diseases and targeted infection of specific tissues or organs. Three different classes of vectors can be derived from HSV-1: replication-competent attenuated vectors, replication-incompetent recombinant vectors and defective helper-dependent vectors known as amplicons. This chapter highlights the current knowledge concerning design, construction and recent applications, as well as the potential and current limitations of the three different classes of HSV-1-based vectors.
Peggy Marconi; Rafaela Argnani; Alberto L Epstein; Roberto Manservigi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  655     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-04     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  118-44     Citation Subset:  IM    
Department of Experimental and Diagnostic Medicine-Section of Microbiology, University of Ferrara, Via Luigi Borsari 46, Ferrara, 44100, Italy.
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MeSH Terms
Antigens, Viral / chemistry
DNA, Viral / genetics
Drug Discovery
Gene Therapy / methods*
Genetic Engineering
Genetic Vectors*
Models, Genetic
Neoplasms / therapy
Simplexvirus / genetics*
Vaccination / methods*
Vaccines / chemistry*
Reg. No./Substance:
0/Antigens, Viral; 0/DNA, Viral; 0/Vaccines

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