Document Detail

HST1, a new member of the SIR2 family of genes.
MedLine Citation:
PMID:  8810037     Owner:  NLM     Status:  MEDLINE    
A novel Saccharomyces cerevisiae gene, HST1, was identified from among anonymous cDNAs and the complete corresponding genomic clone was isolated and sequenced. HST1 is very closely related to SIR2, showing 71% sequence identity over 84% of its length. Polymerase chain reaction with degenerate primers on S. cerevisiae DNA identified three additional SIR2-related genes designated HST2, HST3 and HST4. The sequences of HST2, HST3 and HST4 correspond to sequences previously released by the S. cerevisiae genome sequencing project as U33335, NCBI gi:965078; X87331, NCBI gi:829135; and Z48784, YD9346.03, respectively. Disruption of HST1 has shown no phenotype with respect to mechanisms in which SIR2 has a role, namely, regional silencing of HML alpha, or in rDNA recombination.
M K Derbyshire; K G Weinstock; J N Strathern
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Yeast (Chichester, England)     Volume:  12     ISSN:  0749-503X     ISO Abbreviation:  Yeast     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1997-02-24     Completed Date:  1997-02-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8607637     Medline TA:  Yeast     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  631-40     Citation Subset:  IM    
Gene Regulation and Chromosome Biology Laboratory, NCI-Frederick Cancer Research and Development Center, ABL-Basic Research Program, Maryland 21702-1201, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/L47120;  M97690;  U33335;  X72225;  X87331;  Z48784
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MeSH Terms
Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA Primers / genetics
DNA, Fungal / genetics
DNA-Binding Proteins / genetics
Fungal Proteins / genetics*
Gene Deletion
Genes, Fungal*
Histone Deacetylases*
Molecular Sequence Data
Multigene Family*
Recombination, Genetic
Saccharomyces cerevisiae / genetics*
Saccharomyces cerevisiae Proteins*
Sequence Homology, Amino Acid
Silent Information Regulator Proteins, Saccharomyces cerevisiae*
Sirtuin 1
Sirtuin 2
Trans-Activators / genetics
Grant Support
Reg. No./Substance:
0/DNA Primers; 0/DNA, Fungal; 0/DNA-Binding Proteins; 0/Fungal Proteins; 0/Saccharomyces cerevisiae Proteins; 0/Silent Information Regulator Proteins, Saccharomyces cerevisiae; 0/Trans-Activators; EC 3.5.1.-/HST1 protein, S cerevisiae; EC 3.5.1.-/SIR2 protein, S cerevisiae; EC 3.5.1.-/SIRT1 protein, human; EC 3.5.1.-/Sirtuin 1; EC 3.5.1.-/Sirtuin 2; EC 3.5.1.-/Sirtuins; EC Deacetylases

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