Document Detail


HSP70 and HSP90 expression in leucocytes after exercise in moderately trained humans.
MedLine Citation:
PMID:  12028134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we examined expression of heat shock proteins (HSP) 70 and 90 in human leucocytes after moderate-to-heavy exercise. We also compared baseline levels of HSP70 and HSP90 in trained (TR) and untrained (UT) subjects. Eleven TR subjects ran on a treadmill for 1 h at 70% of maximal oxygen consumption. The HSP levels were measured prior to exercise and 15 and 24 h after exercise. Baseline HSP levels were also measured in eight UT controls. Fifteen hours and 24 h after exercise, TR subjects showed no significant increases in HSP70 (P > 0.05). The HSP90 levels also did not change (P > 0.05). Baseline HSP70 levels in TR subjects were lower than in UT subjects (2.04 +/- 0.51 ng vs. 4.52 +/- 0.95 ng, P < 0.05), while HSP90 levels were similar in TR and UT subjects. We conclude that exercise at an intensity that is within normal limits for a moderately trained individual is not a sufficient stimulus of HSP70 production in leucocytes. We also conclude that blunted levels of baseline HSP70 expression in TR subjects might be a chronic adaptation to training.
Authors:
S Shastry; D O Toft; M J Joyner
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  175     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-24     Completed Date:  2002-09-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  139-46     Citation Subset:  IM    
Affiliation:
Department of Physiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Adult
Blotting, Western
Body Composition
Body Weight
Down-Regulation
Electrophoresis, Polyacrylamide Gel
Exercise / physiology*
Female
HSP70 Heat-Shock Proteins / metabolism*
HSP90 Heat-Shock Proteins / metabolism*
Humans
Leukocytes / metabolism*
Male
Oxygen Consumption
Grant Support
ID/Acronym/Agency:
HL46493/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/HSP70 Heat-Shock Proteins; 0/HSP90 Heat-Shock Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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