| HSP 27 as possible prognostic factor in patients with oral squamous cell carcinoma. | |
| | |
MedLine Citation:
|
PMID: 14702179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
HSP27 belongs to the Heat shock protein (HSP) family, which plays essential functions in cells under physiological conditions and prevents stress-induced cellular damage. The aim of this study was to investigate the biological role of HSP27 in oral tumorigenesis. MATERIALS AND METHODS: Seventy-nine cases of oral squamous cell carcinoma and 10 cases of normal mucosa were analysed for HSP27 expression by immunohistochemistry. Moreover, the western blot analysis was performed on two cases of normal mucosa and five cases of OSCC. RESULTS: Normal oral mucosa showed a suprabasal expression of HSP27. Twenty-four cases of SCC (30.7%) showed a diffuse staining for HSP27, and 48 cases (60.3%) showed instead a decrease in staining, which was diffuse, homogeneous, or with alternation of positive and negative areas in a single tumor ("mosaic" pattern). Only 7 cases of OSCC (7.5%) were completely negative for HSP27. Frequency of lymph node metastases was higher in HSP27-negative tumours (3/7, 42.8%) than in HSP-reduced (16/48, 33.3%) or positive ones (5/26, 19.2%). Regard staging, stages I and II had a higher score than stages III and IV (stage I > stage II > stage III > stage IV). There was also a statistically significant correlation between HSP27 expression and grade: HSP27 expression was reduced in poorly differentiated tumours (P < 0.05). When analysed for prognostic significance, patients with negative/reduced HSP27 expression had poorer survival rates than the group with positive HSP27 expression (P < 0.05). The statistical analysis of these findings showed no significant correlation between HSP27 expression, sex, and tumour size. CONCLUSION: Cases with reduced expression were more aggressive and poorly differentiated. These data suggest that HSP27 expression may be useful in order to identify cases of oral squamous cell carcinoma with more aggressive and invasive phenotype providing novel diagnostic and prognostic information on individual patient survival with oral cancers. |
| | |
Authors:
|
L Lo Muzio; R Leonardi; M A Mariggiò; M D Mignogna; C Rubini; A Vinella; G Pannone; L Giannetti; R Serpico; N F Testa; G De Rosa; S Staibano |
Related Documents
:
|
20566859 - Kinesin-associated protein 3 (kifap3) has no effect on survival in a population-based c... 8955659 - Prediction of colorectal cancer relapse and survival via tissue rna levels of matrix me... 17890889 - Analysis of molecular pathological factors of unfavorable prognosis for young cervical ... 12947069 - Loss of p16 expression is of prognostic significance in locally advanced prostate cance... 11956619 - Expression of dihydrodiol dehydrogenase in the resected stage i non-small cell lung can... 16467169 - Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer. 7400209 - Comparison of survival in nonresected well differentiated and poorly differentiated ade... 12103369 - Completion pneumonectomy for non-small cell lung cancer: experience with 59 cases. 1524919 - Neoadjuvant chemotherapy in 126 operable breast cancers. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Histology and histopathology Volume: 19 ISSN: 0213-3911 ISO Abbreviation: Histol. Histopathol. Publication Date: 2004 Jan |
Date Detail:
|
Created Date: 2003-12-31 Completed Date: 2004-08-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8609357 Medline TA: Histol Histopathol Country: Spain |
Other Details:
|
Languages: eng Pagination: 119-28 Citation Subset: IM |
Affiliation:
|
Institute of Dental Sciences, University of Ancona, Ancona, Italy. lomuziol@tin.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Blotting, Western Carcinoma, Squamous Cell / diagnosis*, mortality, pathology* Female Heat-Shock Proteins / diagnostic use* Humans Immunohistochemistry Italy Lymphatic Metastasis Male Middle Aged Mouth Neoplasms / diagnosis*, mortality, pathology* Neoplasm Staging Prognosis Survival Rate |
| Chemical | |
Reg. No./Substance:
|
0/Heat-Shock Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Syncytial giant cell component. Review of 55 renal cell carcinomas.
Next Document: The prognostic significance of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine d...