Document Detail

HS-SPME-GC-MS analysis of body odor to test the efficacy of foot deodorant formulations.
MedLine Citation:
PMID:  19832965     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/PURPOSE: Foot malodor is mostly due to short-chain fatty acids produced by bacterial metabolism of eccrine sweating. We aimed to develop a protocol for an objective (instrumental) efficacy evaluation of foot deodorant formulations. METHODS: Head-space solid-phase microextractions of target fatty acids from the feet of six healthy volunteers were analyzed by GC-MS. A comparative analysis of the treated vs. the untreated foot was performed in each subject after washing the feet with a physiologic solution and incubating at 36 degrees C for 24-72 h in tryptic soy agar growth medium. RESULTS: Acetic, butyric, isobutyric and isovaleric acids were identified as the main contributors to foot malodor in the majority of volunteers. Propionic, valeric and isocaproic acids were also detected in some subjects. Comparative analysis according to the protocol developed showed a statistically significant (P<0.01) reduction of target fatty acids ranging from -26.6% to -77.0%. CONCLUSION: The protocol developed is a convenient, sensitive and non-invasive method to test the efficacy of foot deodorant formulations in human volunteers.
Alessandro Caroprese; Simone Gabbanini; Claudia Beltramini; Elena Lucchi; Luca Valgimigli
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)     Volume:  15     ISSN:  1600-0846     ISO Abbreviation:  Skin Res Technol     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2010-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504453     Medline TA:  Skin Res Technol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  503-10     Citation Subset:  IM    
Department of Organic Chemistry A Mangini, University of Bologna, Bologna, Italy.
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MeSH Terms
Acetic Acid / analysis
Butyric Acid / analysis
Butyric Acids / analysis
Deodorants / therapeutic use*
Drug Monitoring / instrumentation,  methods
Emollients / therapeutic use
Fatty Acids, Volatile / analysis*
Gas Chromatography-Mass Spectrometry / methods*
Odors / analysis,  prevention & control*
Pentanoic Acids / analysis
Sensitivity and Specificity
Sweat / chemistry
Reg. No./Substance:
0/Butyric Acids; 0/Deodorants; 0/Emollients; 0/Fatty Acids, Volatile; 0/Pentanoic Acids; 107-92-6/Butyric Acid; 503-74-2/isovaleric acid; 64-19-7/Acetic Acid; 79-31-2/isobutyric acid

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