Document Detail

HPV type 16 in conjunctival and junctional papilloma, dysplasia, and squamous cell carcinoma.
MedLine Citation:
PMID:  8567996     Owner:  NLM     Status:  MEDLINE    
AIMS: To clarify the role of human papillomavirus (HPV) infection in the development of papilloma, dysplasia, squamous cell carcinoma, and basal cell epithelioma arising from the eyelids, including the tunica conjunctiva palpebrum (conjunctiva), its junction to epidemis of eyelid skin (junction), and eyelid skin. METHODS: Sixteen cases of papilloma, four of dysplasia, four of squamous cell carcinoma, and 12 of basal cell epithelioma were examined using formalin fixed and paraffin embedded samples. Detection of HPV-DNA was performed by PCR-RFLP and in situ hybridisation (ISH) methods. RESULTS: HPV-16 was detected in 12/16 papillomas (75%), 2/4 dysplasias (50%), and 1/4 squamous cell carcinomas (25%) but in none of the basal cell epitheliomas. No other HPV subtypes were found. ISH assay showed positive signals in only two cases of dysplasia and squamous cell carcinoma. The mean age of HPV-16 positive dysplasia and squamous cell carcinoma cases (81.7 years) was significantly higher than that of HPV-16 positive papilloma cases (p < 0.01). CONCLUSIONS: Based on the presence of HPV-16 in both benign and malignant lesions and the age distribution, it seems likely that HPV-16 alone may be incapable of causing development of conjunctival and junctional dysplasia and squamous cell carcinoma, and that any correlation between the papilloma-squamous cell carcinoma sequence and HPV infection may be due to rare events.
M Saegusa; Y Takano; M Hashimura; I Okayasu; J Shiga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  48     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-03-06     Completed Date:  1996-03-06     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1106-10     Citation Subset:  AIM; IM    
Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
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MeSH Terms
Age Distribution
Aged, 80 and over
Carcinoma, Squamous Cell / virology*
Conjunctival Neoplasms / virology*
DNA, Viral / analysis
Eyelid Neoplasms / virology*
In Situ Hybridization
Middle Aged
Papilloma / virology*
Papillomaviridae / classification,  isolation & purification*
Polymerase Chain Reaction
Precancerous Conditions / virology
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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