Document Detail

HPMA copolymers for modulating cellular signaling and overcoming multidrug resistance.
MedLine Citation:
PMID:  20005272     Owner:  NLM     Status:  MEDLINE    
Unique properties of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer granted its wide use as a carrier for different nanotherapeutics. However, the role of HPMA in a drug delivery system is not limited solely to a carrier for an active payload. Detailed investigations revealed its deep influence on the molecular mechanisms of antitumor action of chemotherapeutic drugs bound to HPMA copolymer. Such influence involves changing the internalization and intracellular trafficking of an entire HPMA-drug complex, modifying the topography of the accumulation of delivered anticancer drug in the tumor and inside tumor cells, overcoming and suppression of existing drug resistance and preventing its de novo development, inhibition of cellular drug detoxification and intracellular repair mechanisms, affecting cell death signaling pathways and mechanisms of apoptosis and necrosis induction. The present review underlines the major mechanisms of the aforementioned effects leading to the substantial enhancement of cell death-inducing ability of conjugated anticancer drugs.
Tamara Minko
Publication Detail:
Type:  Journal Article; Review     Date:  2009-12-11
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  62     ISSN:  1872-8294     ISO Abbreviation:  Adv. Drug Deliv. Rev.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  192-202     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier B.V. All rights reserved.
Department of Pharmaceutics, Ernest Mario School of Pharmacy Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA.
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MeSH Terms
Acrylamides / chemistry,  pharmacology*
Cell Death / drug effects,  physiology
Cell Line, Tumor
Drug Resistance, Multiple / drug effects*,  physiology
Drug Resistance, Neoplasm / drug effects
Polymers / chemistry,  pharmacology*
Signal Transduction / drug effects*,  physiology
Reg. No./Substance:
0/Acrylamides; 0/Polymers; 21442-01-3/N-(2-hydroxypropyl)methacrylamide

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