Document Detail


HPLC determination of glycyrrhizin and glycyrrhetic acid in biological fluids, after licorice extract administration to humans and rats.
MedLine Citation:
PMID:  7654308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Simple and sensitive HPLC methods were developed for the determination of glycyrrhyzin (G) and its main metabolite glycyrrhetic acid (GA) in biological samples, in order to investigate the pharmacokinetic behaviour of G after oral administration of licorice extract (LE) or G to humans and rats. The analysis have been carried out by HPLC with UV detector (251 nm), after a careful pretreatment of the samples. These methods are suitable in terms of precision and accuracy for the G and GA determination in plasma and urine of human volunteers and in bile, plasma ad urine of rats.
Authors:
M A Raggi; F Bugamelli; L Nobile; P Schiavone; G Cantelli-Forti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bollettino chimico farmaceutico     Volume:  133     ISSN:  0006-6648     ISO Abbreviation:  Boll Chim Farm     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-10-03     Completed Date:  1995-10-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372534     Medline TA:  Boll Chim Farm     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  704-8     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, University of Bologna, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents / analysis*,  pharmacokinetics
Chromatography, High Pressure Liquid
Glycyrrhetinic Acid / analogs & derivatives*,  analysis,  pharmacokinetics
Glycyrrhiza*
Glycyrrhizic Acid
Humans
Plant Extracts / analysis,  pharmacokinetics
Plants, Medicinal*
Rats
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Plant Extracts; 1405-86-3/Glycyrrhizic Acid; 471-53-4/Glycyrrhetinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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