Document Detail

HPA-axis function, symptoms, and medication exposure in youths at clinical high risk for psychosis.
MedLine Citation:
PMID:  22892058     Owner:  NLM     Status:  MEDLINE    
AIM: Increased basal cortisol secretion has been associated with heightened clinical risk for psychosis, and among at-risk individuals, has been variably related to positive and mood symptoms, as well as clinical outcome.
METHODS: Basal salivary cortisol secretion was assessed in 33 patients at clinical high risk (CHR) for psychosis (21 medication-free and 12 taking a serotonin reuptake inhibitor and/or atypical antipsychotic), and 13 healthy controls. Among the CHR patients, we also examined associations of basal salivary cortisol with symptoms (positive, negative, mood, stress sensitivity) and clinical outcome.
RESULTS: Basal salivary cortisol secretion was significantly higher in CHR patients who were medication-free compared to CHR patients taking medications and to healthy controls. In this small cohort, basal salivary cortisol secretion was associated at trend level with stress sensitivity, and was not significantly related to other symptoms.
CONCLUSIONS: Our finding of elevated basal cortisol secretion in CHR patients supports the premise that excess activation of the HPA axis and/or neuroendocrine abnormalities characterize the psychosis risk state for at least a subset of patients. Our findings further suggest that psychotropic medications may have a normalizing effect on HPA-axis dysfunction in CHR patients, which could potentially inform intervention strategies for the prodrome.
G Sugranyes; J L Thompson; C M Corcoran
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-11
Journal Detail:
Title:  Journal of psychiatric research     Volume:  46     ISSN:  1879-1379     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-04-05     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1389-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Servei de Psiquiatria i Psicologia Infantil i Juvenil, Institut de Neurociències, Hospital Clínic de Barcelona, c. Villarroel 140, 08015 Barcelona, Spain.
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MeSH Terms
Antipsychotic Agents / therapeutic use
Clinical Trials, Phase I as Topic / methods
Cohort Studies
Hydrocortisone / metabolism*,  secretion
Hypothalamo-Hypophyseal System / metabolism*,  secretion
Pituitary-Adrenal System / metabolism*,  secretion
Psychotic Disorders / drug therapy*,  metabolism,  physiopathology*
Serotonin Uptake Inhibitors / therapeutic use
Stress, Psychological / metabolism
Young Adult
Grant Support
Reg. No./Substance:
0/Antipsychotic Agents; 0/Serotonin Uptake Inhibitors; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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