| HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR). | |
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MedLine Citation:
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PMID: 18639608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caregiving stress is associated with negative health outcomes. Neuroendocrine functioning may be a mediator of such outcomes. The MAOA gene regulates activity of neurotransmitters involved with neuroendocrine responses to stress. Differences in polymorphisms of this gene have been shown to influence susceptibility to stress. Therefore, we examined allelic variation in MAOA-uVNTR, a functional polymorphism of MAOA, as a moderator of chronic stress effects on urinary cortisol excretion in 74 males enrolled in a case/control study of caregivers for relatives with dementia. Mixed models analysis of variance were used to examine MAOA-uVNTR genotype (3 repeats vs. 3.5/4 repeats) as a moderator of the impact of stress (caregiver vs. non-caregiver) on the urinary excretion pattern (overnight, daytime, evening) of cortisol. Caregivers with MAOA-uVNTR alleles associated with less transcriptional activity (3-repeats) displayed a pattern of cortisol excretion -- a decrease from overnight to daytime -- that was suggestive of HPA axis blunting, as compared to non-caregivers and those caregivers with the more active alleles (3.5/4 repeats) (cortisol p<.043). Individuals with less active MAOA-uVNTR alleles who are under chronic stress may be at increased risk for exhaustion of the HPA response to such stress. |
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Authors:
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Beverly H Brummett; Stephen H Boyle; Ilene C Siegler; Cynthia M Kuhn; Richard S Surwit; Melanie E Garrett; Ann Collins; Allison Ashley-Koch; Redford B Williams |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-07-01 |
Journal Detail:
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Title: Biological psychology Volume: 79 ISSN: 1873-6246 ISO Abbreviation: Biol Psychol Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-10 Completed Date: 2009-04-08 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 0375566 Medline TA: Biol Psychol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 250-5 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. brummett@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Caregivers / psychology* Case-Control Studies Circadian Rhythm / physiology Dementia / nursing Genotype Humans Hydrocortisone / urine Male Middle Aged Minisatellite Repeats / genetics* Monoamine Oxidase / genetics* Stress, Psychological / etiology, genetics*, urine* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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3P01 HL036587/HL/NHLBI NIH HHS; M01 RR30L/RR/NCRR NIH HHS; P01 HL036587/HL/NHLBI NIH HHS; P01 HL036587-19/HL/NHLBI NIH HHS; P30 AG028716/AG/NIA NIH HHS; R01 AG019605/AG/NIA NIH HHS; R01 AG019605-04/AG/NIA NIH HHS; R01 AG19605/AG/NIA NIH HHS; R01 MH57663/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; EC 1.4.3.4/Monoamine Oxidase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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