| HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. | |
| | |
MedLine Citation:
|
PMID: 22248666 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In this work, we designed and developed a two-stage delivery system composed of enteric capsule and cationic nanoparticles for oral delivery of insulin. The enteric capsule was coated with pH-sensitive hydroxypropyl methylcellulose phthalate (HP55), which could selectively release insulin from nanoparticles in the intestinal tract, instead of stomach. The biodegradable poly(lactic-co-glycolic acid) (PLGA) was selected as the matrix for loading insulin. Eurdragit(®) RS (RS) was also introduced to the nanoparticles for enhancing the penetration of insulin across the mucosal surface in the intestine. The nanoparticles were prepared with the multiple emulsions solvent evaporation method via ultrasonic emulsification. The optimized nanoparticles have a mean size of 285nm, a positive zeta potential of 42mV. The encapsulation efficiency was up to 73.9%. In vitro results revealed that the initial burst release of insulin from nanoparticles was markedly reduced at pH 1.2, which mimics the stomach environment. In vivo effects of the capsule containing insulin PLGA/RS nanoparticles were also investigated in diabetic rat models. The oral delivered capsules induced a prolonged reduction in blood glucose levels. The pharmacological availability was found to be approximately 9.2%. All the results indicated that the integration of HP55-coated capsule with cationic nanoparticles may be a promising platform for oral delivery of insulin with high bioavailability. |
| | |
Authors:
|
Zhi Min Wu; Liying Zhou; Xin Dong Guo; Wei Jiang; Li Ling; Yu Qian; Kathy Qian Luo; Li Juan Zhang |
Related Documents
:
|
10389856 - The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycog... 7758256 - Clinical characteristics of subjects with a missense mutation in glucokinase. 3593296 - Heterogeneity of glucose-6-phosphate dehydrogenase enzymopathies in the gdr. 17026496 - Obesity risk associated with the k121q polymorphism of the glycoprotein pc-1 gene. 22237686 - Impact of maternal diabetes on birthweight is greater in non-hispanic blacks than in no... 22576256 - Incidence of type 1 diabetes in childhood before and after the reunification of germany... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
|
Title: International journal of pharmaceutics Volume: - ISSN: 1873-3476 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
|
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impact of Conventional Breath Inspiratory Time during High-Frequency Jet Ventilation in Preterm Lamb...
Next Document: Thermosensitive eyedrops containing platelet lysate for the treatment of corneal ulcers.