| HNA-1a, HNA-1b and HNA-1c gene frequencies in Argentineans. | |
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MedLine Citation:
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PMID: 18416775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human neutrophil antigens (HNA) are polymorphic structures located in the neutrophil membrane. The neutrophil-specific antigens HNA-1a (NA1), 1b (NA2) and 1c (SH) are well-recognized allotypic forms of FcgammaRIIIb and the most frequent targets of neutrophil alloantibodies. The aim of this study was to determine the gene frequencies of the neutrophil-specific antigens belonging to the HNA-1 system in blood donors and Toba Amerindians from Rosario, Argentina. Two hundred and eighteen unrelated healthy Argentinean blood donors and Toba Amerindians from Rosario were typed for HNA-1a, HNA-1b and HNA-1c using polymerase chain reaction with sequence-specific primers. For the Argentinean blood donors, the HNA-1a and HNA-1b gene frequencies were 0.44 and 0.56 and for the Amerindians Toba were 0.77 and 0.23, respectively. The HNA-1c antigen is present in 4.7% (gene frequency=0.023) of the blood donors but in none of the Amerindian individuals. The present data showed that the HNA-1 allele frequencies in the major population and the Toba Amerindians from Rosario are similar to those described in European and others distant Amerindians populations, respectively. |
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Authors:
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C D de La Vega Elena; N Nogués; A Fernández Montoya; S Oyonarte; E Solis; E Muñiz-Díaz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Tissue antigens Volume: 71 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-17 Completed Date: 2008-08-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: Denmark |
Other Details:
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Languages: eng Pagination: 475-7 Citation Subset: IM |
Affiliation:
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Servicio de Medicina Transfusional, Hospital Italiano Garibaldi, Rosario, Argentina. daniel.delavega@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Argentina Ethnic Groups / genetics* Gene Frequency* Genotype Humans Indians, South American / genetics* Isoantigens / genetics* Neutrophils / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Isoantigens; 0/neutrophil-specific antigen NA1, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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