Document Detail

HMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathway.
MedLine Citation:
PMID:  22355763     Owner:  NLM     Status:  PubMed-not-MEDLINE    
High-mobility group AT-hook 1 (HMGA1) protein is an important nuclear factor that activates gene transcription by binding to AT-rich sequences in the promoter region of DNA. We previously demonstrated that HMGA1 is a key regulator of the insulin receptor (INSR) gene and individuals with defects in HMGA1 have decreased INSR expression and increased susceptibility to type 2 diabetes mellitus. In addition, there is evidence that intracellular regulatory molecules that are employed by the INSR signaling system are involved in post-translational modifications of HMGA1, including protein phosphorylation. It is known that phosphorylation of HMGA1 reduces DNA-binding affinity and transcriptional activation. In the present study, we investigated whether activation of the INSR by insulin affected HMGA1 protein phosphorylation and its regulation of gene transcription. Collectively, our findings indicate that HMGA1 is a novel downstream target of the INSR signaling pathway, thus representing a new critical nuclear mediator of insulin action and function.
Eusebio Chiefari; Maria T Nevolo; Biagio Arcidiacono; Elisa Maurizio; Aurora Nocera; Stefania Iiritano; Riccardo Sgarra; Katiuscia Possidente; Camillo Palmieri; Francesco Paonessa; Giuseppe Brunetti; Guidalberto Manfioletti; Daniela Foti; Antonio Brunetti
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Publication Detail:
Type:  Journal Article     Date:  2012-02-07
Journal Detail:
Title:  Scientific reports     Volume:  2     ISSN:  2045-2322     ISO Abbreviation:  Sci Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-22     Completed Date:  2012-09-10     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101563288     Medline TA:  Sci Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  251     Citation Subset:  -    
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