Document Detail


HMG-CoA reductase inhibitors for lowering elevated levels of C-reactive protein.
MedLine Citation:
PMID:  15540478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Clinical trials evaluating the effectiveness of therapy with hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors for reducing elevated C-reactive protein (CRP) levels and associated coronary events are reviewed. SUMMARY: Atherosclerotic plaque growth may be attenuated with therapy aimed at minimizing inflammation. Because increased levels of CRP have been associated with arterial-wall inflammation, statins can prevent ischemia by both inhibiting deposition of lipids and decreasing inflammation. Evaluation of recent clinical trials, including WOSCOPS, PRINCE, AFCAPS/ TexCAPS, MIRACL, CURVES, REVERSAL, and JUPITER, demonstrated the correlation of statin therapy with decreased levels of CRP. WOSCOPS found that patients with CRP values of > 4.59 mg/L at baseline were at the highest risk of coronary events. The PRINCE trial evaluated the antiinflammatory effects of pravastatin and found a mean 16.9% reduction in CRP levels after 24 weeks of therapy. AFCAPS/TexCAPS researchers found that lovastatin provded a 14.8% reduction in the median levels of CRP (p < 0.001). The MIRACL study showed that atorvastatin reduced CRP levels by 83% (p < 0.001). Researchers in the CURVES study found a significant reduction in CRP levels with pravastatin, simvastatin, and atorvastatin compared with baseline (p < 0.025). Results of the REVERSAL study linked atorvastatin with a 36.4% decrease in CRP levels, while pravastatin was associated with a 5.2% decrease (p < 0.0001). JUPITER is ongoing and will determine whether long-term use of rosuvastatin can reduce the rate of coronary events. CONCLUSION: The lowering of elevated CRP levels by statins may reduce the risk of coronary events independently of the effect of statins on lipid levels.
Authors:
Kristine Y Chan; Elizabeth S Boucher; Pritesh J Gandhi; Matthew A Silva
Related Documents :
15857308 - Ezetimibe and other azetidinone cholesterol absorption inhibitors.
17420348 - Adherence to statin therapy under drug cost sharing in patients with and without acute ...
16085718 - Coronary microvascular dysfunction in male patients with anderson-fabry disease and the...
11889008 - Relationship between lipid levels and clinical outcomes in the long-term intervention w...
19092738 - Outcome of atrial fibrillation ablation: assessment of success.
9416928 - Clinical and prognostic significance of atrial fibrillation in acute myocardial infarct...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists     Volume:  61     ISSN:  1079-2082     ISO Abbreviation:  Am J Health Syst Pharm     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-11-15     Completed Date:  2004-12-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9503023     Medline TA:  Am J Health Syst Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1676-81     Citation Subset:  IM    
Affiliation:
St. Luke's Medical Center, Milwaukee, WI, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
C-Reactive Protein / antagonists & inhibitors*,  metabolism
Clinical Trials as Topic
Coronary Artery Disease / drug therapy,  metabolism,  prevention & control
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute postoperative hypertension: a review of therapeutic options.
Next Document:  Stability of meropenem in polyvinyl chloride bags and an elastomeric infusion device.