Document Detail


HMG CoA reductase inhibitors are related to improved systemic endothelial function in coronary artery disease.
MedLine Citation:
PMID:  10559508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (statins) may enhance vascular endothelial function independent of their cholesterol lowering effect. To test this hypothesis, we surveyed two groups of patients (age 55+/-7, mean+/-SD) with coronary artery disease that were matched for age, blood pressure and serum lipid levels. Group 1 comprised 23 men without lipid-lowering medication and Group 2 included 22 patients with ongoing HMG CoA reductase inhibitor medication. Flow-mediated (endothelium-dependent) arterial dilatation (FMD) and nitrate-mediated (smooth muscle dependent) dilatation (NMD) were measured in the brachial artery using high resolution ultrasound. FMD was considerably higher in group 2 (4.3+/-2.6 vs. 2.6+/-2.8%; P<0.05). In multivariate regression model, statin use was the only significant (P<0.05) predictor of FMD. In all subjects, FMD correlated with statin dose (P<0.05 for trend). NMD was non-significantly higher in group 2 (11.4+/-5.0 vs. 9.0+/-4.2%, P=0. 08). We conclude that patients with established coronary artery disease on HMG CoA reductase inhibitor therapy have better vascular endothelial function than similar patients without the medication. These data provide further support for the idea that HMG CoA reductase inhibitors enhance endothelial function independent of their lipid-lowering effects. This may suggest that these drugs could be beneficial in secondary prevention of coronary artery disease regardless of the serum cholesterol concentration.
Authors:
M J Järvisalo; J O Toikka; T Vasankari; J Mikkola; J S Viikari; J J Hartiala; O T Raitakari
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  147     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  237-42     Citation Subset:  IM    
Affiliation:
Department of Clinical Physiology, Turku University Central Hospital, Turku, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Analysis of Variance
Cholesterol, HDL / blood,  drug effects
Cholesterol, LDL / blood,  drug effects
Coronary Angiography
Coronary Disease / drug therapy*,  radiography,  ultrasonography
Coronary Vessels / drug effects*,  pathology
Cross-Sectional Studies
Endothelium, Vascular / drug effects*,  physiology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
Linear Models
Male
Middle Aged
Multivariate Analysis
Reference Values
Vascular Patency
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

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