| HLAs in children with minimal change disease and other types of nephrotic syndrome in the southern part of Turkey. | |
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MedLine Citation:
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PMID: 11297154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate the human leukocyte antigen (HLA) profile of children with nephrotic syndrome in the southern part of Turkey. Seventy-eight children with nephrotic syndrome were studied for the frequency of class I and class II human leukocyte antigens. Forty-seven of them were steroid sensitive nephrotic syndrome (minimal change disease-MCD) and 31 were other types of nephrotic syndrome. The results were compared with 133 healthy subjects for HLA groups. HLA B13, Cw5, Cw7, DR4, DR7, DRw10, Drw15(2) and DQ2 in the MCD group and HLA A31, B8, B13, B17, Cw2, Cw6, Cw7, DRw10 and DRw12 in the non-MCD group were found significantly increased when compared to healthy controls. MCD patients with frequent relapses had higher frequencies of both Cw6 and DR1 (p < 0.005) and MCD patients with infrequent relapses had a higher frequency of Cw7 (p < 0.05). In conclusion, HLA groups may help in the early diagnosis of these variants. |
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Authors:
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A Karabay-Bayazit; A Noyan; Y Bayazit; A Ozel; A Anarat |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Turkish journal of pediatrics Volume: 43 ISSN: 0041-4301 ISO Abbreviation: Turk. J. Pediatr. Publication Date: 2001 Jan-Mar |
Date Detail:
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Created Date: 2001-04-11 Completed Date: 2001-05-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0417505 Medline TA: Turk J Pediatr Country: Turkey |
Other Details:
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Languages: eng Pagination: 24-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Cukurova University Faculty of Medicine, Adana, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Chi-Square Distribution Child Female HLA Antigens / immunology* Humans Male Microscopy, Fluorescence Nephrotic Syndrome / immunology* Turkey / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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