Document Detail


HLA typing in Vogt-Koyanagi-Harada syndrome in North Indian patients.
MedLine Citation:
PMID:  17558833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To report the HLA profile of VKH patients from India. METHOD: Forty-one patients and 50 controls were studied. Phenotyping using a lymphocytotoxicity assay was done for HLA-A and -B. DNA-based sequence-specific low resolution typing was done for HLA-DR and -DQ loci. RESULTS: HLA-A9 was over-represented in the patient population (p = 0.01), whereas HLA-A11 (p = 0.03) and HLA-DRB1*13 (p = 0.007) were found to be underrepresented. The frequency of HLA-DRB1*04 was 14.6% and 10% in the patient population and controls, respectively. The HLA-DQ frequencies did not differ significantly between patients and controls. CONCLUSION: Unlike that reported in most populations, we did not find a significant association between HLA-DRB1*04 and our patient population.
Authors:
Amod Gupta; Shivali Kamal; Vishali Gupta; Pradeep Bambery; Babita Kaura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  15     ISSN:  0927-3948     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-06-11     Completed Date:  2007-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-97     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. eyepgi@sify.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alleles
DNA / analysis
DNA Fingerprinting
Female
Follow-Up Studies
Gene Frequency
HLA-A Antigens / genetics,  immunology*
HLA-DQ Antigens / genetics,  immunology*
HLA-DR Antigens / genetics,  immunology*
Histocompatibility Testing*
Humans
India / epidemiology
Male
Middle Aged
Retrospective Studies
Seroepidemiologic Studies
Uveomeningoencephalitic Syndrome / epidemiology*,  immunology*
Chemical
Reg. No./Substance:
0/HLA-A Antigens; 0/HLA-A11; 0/HLA-A9; 0/HLA-DQ Antigens; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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