Document Detail

HLA typing and affective disorders: a study in the Italian population.
MedLine Citation:
PMID:  692836     Owner:  NLM     Status:  MEDLINE    
HLA phenotype distribution was investigated in 91 affective patients. Significant increases over those of the control population were found in HLA-A 29 and in Bw 22 frequencies, while A 10 and A 30 were decreased. No significant difference was shown between the two clinical subgroups (41 unipolar patients and 50 bipolar ones). On comparing our data with those from other authors, Bw 16 was significantly increased. However, a high degree of heterogeneity was also shown for this antigen. Of some interest is the finding that relapsed and non-relapsed patients during long-term lithium therapy display diverging HLA phenotype distributions, with B 5 increased among the non-relapsed subjects.
E Smeraldi; F Negri; A M Melica; R Scorza-Smeraldi; G Fabio; P Bonara; L Bellodi; E Sacchetti; M G Sabbadini-Villa; C L Cazzullo; C Zanussi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuropsychobiology     Volume:  4     ISSN:  0302-282X     ISO Abbreviation:  Neuropsychobiology     Publication Date:  1978  
Date Detail:
Created Date:  1978-12-02     Completed Date:  1978-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7512895     Medline TA:  Neuropsychobiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  344-52     Citation Subset:  IM    
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MeSH Terms
Bipolar Disorder / drug therapy,  genetics,  immunology*
Depression / drug therapy,  genetics,  immunology*
Disease Susceptibility
Ethnic Groups
HLA Antigens / analysis*
Lithium / therapeutic use
Reg. No./Substance:
0/HLA Antigens; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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