| HLA and trisomy 21. Confirmation of a trend of restricted HLA heterogeneity in parents of Down syndrome children. | |
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MedLine Citation:
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PMID: 6231858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As the HLA system could play a role in the in utero selection process against abnormal fetuses, HLA-A and -B antigens were evidenced in 30 children with trisomy 21 and in their parents, using a standard microlymphocytotoxicity test. The comparison group included 60 families among whom 39 had HLA typing for paternity exclusion and 21 had been previously selected for a segregation study. Both groups consisted of nonconsanguineous Caucasians from the same geographical area. The Down syndrome (DS) children did not show a significant association with a specific HLA antigen. However, six out of 30 couples having a DS child showed two antigens shared at the A and/or B locus, compared to seven out of 60 control couples. The shared parental antigens were not selectively inherited, and the proportion of homozygote children at one locus was lower for DS (5/30) than for controls (13/60). These findings demonstrate the same trend as previously published but need to be confirmed by other investigators. Perhaps a strong selective pressure in favor of heterozygotes contributes to a better survival rate, as suggested from histocompatibility studies in animals. |
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Authors:
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S Aymé; P Mercier; R Dallest; J F Mattei |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of human genetics Volume: 36 ISSN: 0002-9297 ISO Abbreviation: Am. J. Hum. Genet. Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-05-02 Completed Date: 1984-05-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370475 Medline TA: Am J Hum Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 405-12 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Down Syndrome / genetics* Female Genetic Markers Genetic Variation* HLA Antigens / genetics* HLA-A Antigens HLA-B Antigens HLA-B35 Antigen Heterozygote Humans Male Parents* |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 0/HLA Antigens; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-B35 Antigen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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