Document Detail

The HLA system and leprosy in Thailand.
MedLine Citation:
PMID:  669704     Owner:  NLM     Status:  MEDLINE    
To investigate immunogenetics of leprosy, 205 leprosy patients (26 with tuberculoid, 57 with borderline-tuberculoid, 21 with borderline, 31 with borderline-lepromatous, and 70 with lepromatous leprosy) have been typed for HLA antigens, and compared with 183 healthy controls from the same region (Northern Thailand). There was no significant difference between the overall group of leprosy patients or the three borderline classes and the controls. The two polar forms, tuberculoid and lepromatous leprosy, however, showed significant associations: HLA-A2 is decreased and HLA-Bw17 is increased in tuberculoid leprosy; HLA-B7 is increased in lepromatous leprosy. When both polar forms are compared with each other, HLA-A2 is significantly higher, HLA-Bw40 lower in patients with lepromatous than in those with tuberculoid leprosy. The results are discussed with respect to the different immune responsiveness in the two polar forms of leprosy.
J Greiner; E Schleiermacher; T Smith; V Lenhard; F Vogel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  42     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-09-15     Completed Date:  1978-09-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  201-13     Citation Subset:  IM    
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MeSH Terms
Continental Population Groups
Gene Frequency
HLA Antigens / genetics*
Leprosy / classification,  diagnosis,  genetics*
Sex Factors
Reg. No./Substance:
0/HLA Antigens

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