Document Detail

HLA and rheumatoid arthritis
MedLine Citation:
PMID:  7313484     Owner:  NLM     Status:  MEDLINE    
In a study on the frequency of the HLA A, B, C and DR antigens seen in 100 controls and 31 patients with rheumatoid arthritis, the authors found a significant increase in the DR4 antigen in rheumatoid arthritis. (50% as against 25%; X2 = 8,5; 0,04 greater than Pc greater than 0,008; RR = 3,43). The other antigens on loci A, B. C and DR are not altered significantly. However the increase in DR4 which does not seem to be related to the severity of the rheumatoid arthritis, seems to be proportional to the level of rheumatoid factor. The authors review literature on HLA in rheumatoid arthritis and the figures for the antigenic frequency of HLA-DR4 are compared with their own results. The findings are of interest especially from a pathogenic point of view.
G Llorca; H Betuel; L Gebuhrer; M P Deslous-Paoli; E André-Fouet; B Bonvoisin; M Bouvier; E Lejeune
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Revue du rhumatisme et des maladies ostéo-articulaires     Volume:  48     ISSN:  0035-2659     ISO Abbreviation:  Rev Rhum Mal Osteoartic     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0407211     Medline TA:  Rev Rhum Mal Osteoartic     Country:  FRANCE    
Other Details:
Languages:  fre     Pagination:  691-6     Citation Subset:  IM    
Vernacular Title:
HLA et polyarthrite rhumatoïde.
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MeSH Terms
Arthritis, Rheumatoid / genetics,  immunology*
HLA Antigens / analysis*,  genetics
Middle Aged
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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