Document Detail


HLA polymorphism and early rheumatoid arthritis in the Moroccan population.
MedLine Citation:
PMID:  18801688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Rheumatoid arthritis (RA) is an autoimmune multifactorial disease which has a great socio-economic impact in Morocco. The association of HLA genes with RA was studied in various ethnic groups but not in the Moroccan population. Our study focused on evaluating the distribution of class I and class II HLA genes among Moroccan patients presenting early signs of RA. METHODS: Forty nine patients diagnosed with early RA were compared to a group of healthy controls matched by age, sex, and ethnic origin. Among the patient group, 34 were seropositive (presence of the rheumatoid factor). HLA typing of the patients and the controls was performed using microlymphocytotoxicity for class I (A and B) and PCR-SSP for class II (DR and DQ). RESULTS: We found a significant increase of the frequency of the HLA-A24 antigen (p=0.03), the DRB1*04 (p=0.004) and DQB1*03 (p=0.03) alleles and a significant decrease of the DRB1*07 allele (p=0.03) in seropositive patients. The analysis of the frequency of the DRB1*01, DRB1*10, and DRB1*14 alleles did not show any difference between the RA patients and the controls. The frequency of DR4-DQ2 and DR4-DQ4 haplotypes was increased in the patients compared to the controls while that of DR7-DQ2 and DR13-DQ6 was decreased. CONCLUSIONS: Our study suggests that DRB1*04 predisposes to RA while DRB1*07 seems protective for the Moroccan patients population. In addition we show the influence of some haplotypes DR-DQ in the susceptibility and protection against the disease.
Authors:
Ouafa Atouf; Karima Benbouazza; Chehrazade Brick; Fatiha Bzami; Naima Bennani; Bouchra Amine; Najia Hajjaj-Hassouni; Najia Hajja-Hassouni; Malika Essakali
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Publication Detail:
Type:  Journal Article     Date:  2008-09-18
Journal Detail:
Title:  Joint, bone, spine : revue du rhumatisme     Volume:  75     ISSN:  1778-7254     ISO Abbreviation:  Joint Bone Spine     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-02-05     Revised Date:  2009-07-16    
Medline Journal Info:
Nlm Unique ID:  100938016     Medline TA:  Joint Bone Spine     Country:  France    
Other Details:
Languages:  eng     Pagination:  554-8     Citation Subset:  IM    
Affiliation:
Service de transfusion sanguine et d'hémovigilance, Unité d'Immunologie, CHU Ibn Sina, Rabat, Moroco. atoufoufa@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group
Arthritis, Rheumatoid / diagnosis,  genetics*
Female
Genetic Predisposition to Disease*
HLA Antigens / genetics*
Haplotypes
Humans
Male
Middle Aged
Morocco
Polymorphism, Single-Stranded Conformational*
Chemical
Reg. No./Substance:
0/HLA Antigens
Comments/Corrections
Erratum In:
Joint Bone Spine. 2009 May;76(3):e1
Note: Hajja-Hassouni, Najia [corrected to Hajjaj-Hassouni, Najia]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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