Document Detail


HLA-multiple sclerosis association in continental Italy and correlation with disease prevalence in Europe.
MedLine Citation:
PMID:  15081263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. The phenotype frequency of DRB1*15 in the patients was significantly higher (0.316 vs. 0.112; p(c)<10(-6); Odds Ratio (OR)=3.64) with no dose effect. DRB1*10 was also significantly increased (OR=2.19; p(c)=0.047) and DRB1*07 decreased (OR=0.60; p(c)=1.3 x 10(-3)) independently of DR15 and of each other. We did not detect an influence of the DR phenotype on disease course, age at onset/diagnosis, gender or familiarity. No association with Class I was detected in a random subset of patients and controls. A comparison of the HLA association data in Northern and Southern European populations shows a parallel between disease prevalence and DR15 frequency.
Authors:
Clara Ballerini; Franca R Guerini; Giovanni Rombolà; Eleonora Rosati; Luca Massacesi; Pasquale Ferrante; Domenico Caputo; Lorenzo Figà Talamanca; Paola Naldi; Maria Liguori; Mehdi Alizadeh; Patricia Momigliano-Richiardi; Sandra D'Alfonso
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  150     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-14     Completed Date:  2004-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  178-85     Citation Subset:  IM    
Affiliation:
Dipartimento di Scienze Neurologiche e Psichiatriche, Univ. Firenze, Florence, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Europe / epidemiology
Female
Genetic Predisposition to Disease*
HLA Antigens / analysis,  genetics*
HLA-DR Antigens / analysis,  genetics
Histocompatibility Antigens Class I / genetics
Histocompatibility Testing / statistics & numerical data
Humans
Italy / epidemiology
Male
Multiple Sclerosis / epidemiology*,  genetics*,  immunology
Phenotype
Sex Distribution
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/HLA-DR Antigens; 0/HLA-DR15; 0/Histocompatibility Antigens Class I; 128338-86-3/HLA-DRB1 antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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