Document Detail


HLA-matching in cyclosporine treated renal transplant recipients: a prospective Swedish-Norwegian multicenter study.
MedLine Citation:
PMID:  3154455     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. In this prospective study of 613 CD and 205 one haplotype mismatched LRD transplant recipients treated with CyA, there was no influence of HLA-matching (A, B, DR or combinations) on graft survival rate at one and two years. 2. Patients who successfully received HLA-DR-matched kidneys (CD or LRD) had fewer rejection episodes during the first six months after transplantation. 3. Three factors significantly reduced the cadaveric graft survival rate: (a) presence of panel reactive T-cell antibodies in a current recipient serum, (b) cold ischemia time beyond 27 hours, and (c) recipient age above 55 years. 4. The survival rate of one haplotype mismatched LRD kidneys was excellent and is considered to be the optimal treatment for uremia also in CyA-treated patients. 5. Based on this study, exchange of well HLA-matched CD kidneys to non-sensitized patients has been terminated provisionally in Scandia-transplant. Exchange of HLA-A, B-matched kidneys will be maintained, however, for sensitized patients inasmuch as this will increase the chance of obtaining a negative cross-match and possibly improve graft survival in this high-risk patient group.
Authors:
G Lundgren; C G Groth; D Albrechtsen; H Brynger; A Flatmark; L Frodin; H Gabel; B Husberg; G Klintmalm; W Maurer
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Clinical transplants     Volume:  -     ISSN:  0890-9016     ISO Abbreviation:  Clin Transpl     Publication Date:  1986  
Date Detail:
Created Date:  1991-04-01     Completed Date:  1991-04-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8812419     Medline TA:  Clin Transpl     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-85     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cyclosporins / therapeutic use
Graft Survival
HLA Antigens
Humans
Kidney Transplantation / immunology*
Prospective Studies
Chemical
Reg. No./Substance:
0/Cyclosporins; 0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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