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HLA haplotype A33-B58-Cw10 may modulate radiographic development of bamboo spine in Taiwanese patients with primary ankylosing spondylitis.
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MedLine Citation:
PMID:  19407364     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the possible relationship between HLA alleles and bony ankylosis of the spine (bamboo spine) in Taiwanese patients with ankylosing spondylitis (AS).
METHODS: A small cohort of HLA-B27 positive AS patients was conducted to analyze the effects of alleles {and haplotypes} on the development of bamboo spine. DNA typing of HLA class I and class II genes were performed by SSP method on primary ankylosing spondylitis patients with bamboo spine (n = 84) and spinal enthesopathy controls (n = 228). Odds ratios with 95% confidence intervals and P value were estimated. Determination of the most probable HLA haplotypes on all patients were constructed by comparison of the alleles carried by each patient with the HLA haplotype database established in Taiwanese population studies using homozygosity approach [1] and by expectation-maximum algorithm [2].
RESULTS: Allele frequencies of HLA A33, B58, Cw10, DR4, DR17 and DQ2 were significantly lower in bamboo patients as compared to non-bamboo controls. In contrast, allele frequencies of A24, B54, Cw15, DR11 and DR14 were significantly higher in bamboo patients. Less remarkably, high frequencies of B39, B51, Cw1 and Cw2 alleles were also noted in bamboo patients. Considering linkage disequilibria of alleles in haplotypes, HLA-A11-B27-Cw12 was the most common haplotype in both bamboo and non-bamboo groups (95.23% vs. 91.22%, respectively, P = 0.238). {Haplotypes A33-B58-Cw10, A33-B58-Cw10-DR13 and A33-B58-Cw10-DR17} were significantly lower in bamboo patients as compared to those in controls (P < 0.001, P = 0.001, P = 0.002, respectively).
CONCLUSION: Haplotypes A33-B58-Cw10, A33-B58-Cw10-DR13 and A33-B58-Cw10-DR17 showed a strong association with bamboo spine in Taiwanese AS patients. Detection of such haplotypes might be a great aid in the management of patients with the disease.
Ming-Chi Lu; Kuo-Liang Yang; Kuang-Yung Huang; Chien-Hsueh Tung; Su-Qin Liu; Ning-Sheng Lai
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Disease markers     Volume:  26     ISSN:  0278-0240     ISO Abbreviation:  Dis. Markers     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-01     Completed Date:  2009-06-19     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  93-6     Citation Subset:  IM    
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MeSH Terms
Case-Control Studies
Cohort Studies
Gene Frequency
HLA-A Antigens / genetics*
HLA-B Antigens / genetics*
HLA-C Antigens / genetics*
HLA-DQ Antigens / genetics
HLA-DR4 Antigen / genetics
Haplotypes / genetics*
Leukocytes, Mononuclear / metabolism,  pathology
Odds Ratio
Rheumatic Diseases / genetics
Spondylitis, Ankylosing / epidemiology,  genetics*,  pathology*
Taiwan / epidemiology
Reg. No./Substance:
0/HLA-A Antigens; 0/HLA-A*33 antigen; 0/HLA-B Antigens; 0/HLA-C Antigens; 0/HLA-DQ Antigens; 0/HLA-DQ2 antigen; 0/HLA-DR4 Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2009 Hindawi Publishing Corporation.
Received Day: 21 Month: 4 Year: 2009
Accepted Day: 21 Month: 4 Year: 2009
Print publication date: Year: 2009
Electronic publication date: Day: 30 Month: 4 Year: 2009
Volume: 26 Issue: 2
First Page: 93 Last Page: 96
PubMed Id: 19407364
ID: 3833598
Article Id: 976839
DOI: 10.3233/DMA-2009-0619

HLA Haplotype A33-B58-Cw10 May Modulate Radiographic Development of Bamboo Spine in Taiwanese Patients with Primary Ankylosing Spondylitis
Ming-Chi Lu12
Kuo-Liang Yang3
Kuang-Yung Huang1
Chien-Hsueh Tung1
Su-Qin Liu1
Ning-Sheng Lai1*
1Department of AllergyImmunology and RheumatologyDalin Tzu Chi Buddhist HospitalChia YiTaiwan
2College of MedicineTzu Chi UniversityHualienTaiwan
3Buddhist Tzu Chi Stem Cells CenterHualienTaiwan
Correspondence: *Ning-Sheng Lai:

Article Categories:
  • Other

Keywords: HLA, alleles, haplotypes, ankylosing spondylitis, bamboo spine.

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