Document Detail

HLA control in the progression of human papillomavirus infections.
MedLine Citation:
PMID:  9284528     Owner:  NLM     Status:  MEDLINE    
Cellular immunity is likely to be of major importance for the clearance of inapparent or overt infections caused by human papillomaviruses (HPVs). The highly polymorphic class I or class II human leukocyte antigen (HLA) molecules present HPV-derived peptides to cytotoxic (CD8+) or helper (CD4+) T lymphocytes bearing specific receptors and condition the immune responsiveness to HPV infections. Recent data point to a role of an altered expression of HLA molecules in the persistence of HPV-induced cervical premalignant lesions and their progression towards invasive carcinoma. Furthermore positive of negative associations of certain HLA alleles or haplotypes with cutaneous of cervical neoplasias have been found. These observations may have important implications in the design of therapy or vaccines aimed at eradicating cervical cancer.
F Breitburd; N Ramoz; J Salmon; G Orth
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in cancer biology     Volume:  7     ISSN:  1044-579X     ISO Abbreviation:  Semin. Cancer Biol.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-10-16     Completed Date:  1997-10-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9010218     Medline TA:  Semin Cancer Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  359-71     Citation Subset:  IM    
Unité Mixte Institut Pasteur/INSERM (U190), Institut Pasteur, Paris, France.
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MeSH Terms
Disease Progression
HLA Antigens / genetics,  immunology*
Histocompatibility Antigens Class I / immunology
Histocompatibility Antigens Class II / immunology
Immunity, Cellular
Papillomavirus Infections / immunology*,  physiopathology
Reg. No./Substance:
0/HLA Antigens; 0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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