| HLA-compatible donor cornea for prevention of allograft reaction. | |
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MedLine Citation:
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PMID: 1083165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our series comprises 80 penetrating grafts. Of the recipient corneas 36 were vascularized. Of the donor corneas 48 were fresh and 32 were cryopreserved. As prophylaxis, we gave topical and systemic prednisolone, combined, in heavily vascularized cases, with azathioprine. Corneal donor-recipient pairs were divided into three groups according to HLA histocompatibility. In Group I (0-1 mismatch) the rate of allograft reaction was 1 in 27, in Group II (2-4 mismatches) it was 4 in 19, and in the untyped Group III 9 in 34. Even when the prognosis was poor, a well-matched donor cornea (Group I) greatly improved the chances of success; when the corneal bed was vascularized, the well-matched donor corneas had a failure rate of 1 in 13, whereas in untyped pairs it was 7 in 18. The importance of possible presensitization is discussed. |
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Authors:
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S Vannas; K Karjalainen; P Ruusuvaara; A Tiilikainen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology Volume: 198 ISSN: 0065-6100 ISO Abbreviation: Albrecht Von Graefes Arch Klin Exp Ophthalmol Publication Date: 1976 Mar |
Date Detail:
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Created Date: 1976-06-02 Completed Date: 1976-06-02 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0044637 Medline TA: Albrecht Von Graefes Arch Klin Exp Ophthalmol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 217-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child Female HLA Antigens / analysis Histocompatibility Testing* Humans Male Middle Aged Refrigeration Tissue Donors Tissue Preservation Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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