| HLA class I molecules reflect an altered host proteome after influenza virus infection. | |
MedLine Citation:
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PMID: 19748539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Class I HLA sample and display peptides from thousands of endogenous proteins at the cell surface. During infection, the influenza virus modifies the host cell proteome by triggering host antiviral responses, hijacking host processes, and inhibiting host mRNA processing. In turn, the catalog of HLA class I peptides that decorate the surface of an infected cell is positioned to reflect an altered host cell proteome. To understand the host-encoded peptides presented by class I molecules after influenza infection, we compared by mass spectrometry (MS) the peptides eluted from the HLA of naive and infected cells. We identified 20 peptide ligands unique to infected cells and 347 peptides with increased presentation after infection. Infection with different influenza strains demonstrated that proteome changes are predominantly strain-specific, with few individual cellular interactions observed for multiple viral strains. Modeling by pathway analysis, however, revealed that strain specific host peptide changes represent different routes to the same destination; host changes mediated by influenza are found predominantly clustered around HLA-B, ACTB, HSP90AB1, CDK2, and ANXA2. The class I HLA proteome scanning of influenza-infected cells therefore indicates how divergent strains of influenza pursue alternate routes to access the same host cell processes. |
Authors:
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Angela Wahl; Fredda Schafer; Wilfried Bardet; William H Hildebrand |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Human immunology Volume: 71 ISSN: 1879-1166 ISO Abbreviation: Hum. Immunol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-01-21 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 8010936 Medline TA: Hum Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 14-22 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Antigen Presentation Cell Line Dogs HeLa Cells Histocompatibility Antigens Class I / chemistry, immunology* Humans Influenza A virus / physiology* Influenza, Human / immunology* Ligands Proteome / analysis* Species Specificity |
| Grant Support | |
ID/Acronym/Agency:
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A1007633-006//PHS HHS; A1007633-006//PHS HHS; HHSN266200400027C//PHS HHS; HHSN266200400027C//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Histocompatibility Antigens Class I; 0/Ligands; 0/Proteome |
| Comments/Corrections | |
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