Document Detail


HLA class I and class II profiles of patients presenting with Sydenham's chorea.
MedLine Citation:
PMID:  10751115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sydenham's chorea (SC) may occur in rheumatic fever (RF) patients without arthritis and carditis. In this study we typed HLA antigens and alleles in patients presenting with the distinct major clinical manifestations of RF, i.e., chorea, carditis, or arthritis, in population and family studies. We evaluated 91 patients with RF for HLA-A, HLA-B, and HLA-DR antigens; of these, 33 had pure chorea, 26 pure carditis, 16 pure arthritis, and 16 carditis plus arthritis. We also typed 24 SC patients and their unaffected siblings for HLA-DRB1 and HLA-DQB1 alleles using molecular methods. HLA-B49 and HLA-DR1 antigens were overrepresented in the total group of patients with RF and in all the subgroups studied, excluding the SC subgroup in which the frequency of HLA-DR1 antigen was not increased. The frequencies of the HLA-DRB1 and HLA-DQB1 alleles in patients with pure chorea were not significantly different from those observed in controls. Similarly, the frequencies of HLA class II alleles in SC patients did not differ significantly from those observed in unaffected siblings. These findings show that immunogenetic susceptibility to RF varies according to the major clinical manifestation presented by the patient.
Authors:
E A Donadi; A G Smith; P Louzada-Júnior; J C Voltarelli; G T Nepom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurology     Volume:  247     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-05-19     Completed Date:  2000-05-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  122-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo. Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alleles
Child
Chorea / genetics*,  immunology*
Female
Histocompatibility Antigens Class I / genetics*,  immunology*
Histocompatibility Antigens Class II / genetics*,  immunology*
Histocompatibility Testing
Humans
Male
Middle Aged
Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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