Document Detail


HLA class II genes in Latvian patients with juvenile rheumatoid arthritis.
MedLine Citation:
PMID:  9027967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PCR-based HLA genotyping was used to analyze the association of HLA-DR and -DQ genes in 127 juvenile rheumatoid arthritis patients and 111 population-based controls from Latvia. The results show DQA1*03 to be positively associated in overall patients and DRB1*01-DQA1*0101-DQB1*0501 to be negatively associated with JRA in overall patients and in polyarthritis patients compared to controls. These data indicate the immunogenetic heterogeneity in the JRA patients, in the disease subgroups and in different ethnic groups. Rheumatoid factor (RF) was assayed in patients (n = 119) and controls (n = 98). RF was present in patients (7/119, 6%) compared to controls (5/98, 5%). None of the DQA1, DQB1 alleles, DQ and DR-DQ haplotypes was associated in seropositive patients compared to seropositive controls. DR1-DQ5 (DQA1*0101-B*0501) was decreased in seronegative patients (11/111, 10%) compared to seronegative controls (24/105, 23%), but the difference was not significant after correction of the p value.
Authors:
I Rumba; A Denisova; A Sochnev; B Nilsson; C B Sanjeevi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tissue antigens     Volume:  49     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-15     Completed Date:  1997-04-15     Revised Date:  2010-10-15    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  56-60     Citation Subset:  IM    
Affiliation:
Clinic of Pediatrics, Medical Academy of Latvia, Riga, Latvia.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Arthritis, Juvenile Rheumatoid / genetics,  immunology*
HLA-DQ Antigens / genetics*
HLA-DR Antigens / genetics*
Humans
Latvia
Rheumatoid Factor / blood
Chemical
Reg. No./Substance:
0/HLA-DQ Antigens; 0/HLA-DQA1; 0/HLA-DQB1 antigen; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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