Document Detail

HLA class II antigens DR4 and DQ8 are associated with allergy to hevein, a major allergen of Hevea latex.
MedLine Citation:
PMID:  9027975     Owner:  NLM     Status:  MEDLINE    
In this study we investigated the relationship between HLA class II alleles and the IgE-specific immune response to the 4.7 kDa polypeptide hevein of Hevea brasiliensis, a major latex allergen, 51 individuals with immediate-type latex allergy and 90 controls were examined for the polymorphisms in exon 2 of HLA-DRB1, 3, 4, 5 and DQB1 by sequence-specific oligonucleotide probe typing. 35 (69%) out of 51 latex-sensitized subjects showed positive hevein-specific IgE values. Analysis of the HLA data among these 35 subjects revealed increased phenotype frequencies for DR4 (22/35, 63%) and DQ8 (18/35, 51%) when compared with those in the 16 hevein-negative but latex-positive subjects (DR4: 2/16, 13%, p = 0.0009, Pc = 0.047; DQ8: 0/16, p = 0.0003, pc = 0.018) and with healthy controls (DR4: 22/90, 24%, p = 0.00012, pc = 0.013; DQ8: 16/89, 18%, p = 0.0003, pc = 0.036). Finally the DR4-DQ8 haplotype frequency was significantly elevated in hevein-positives when compared with hevein-negatives (51% vs. 0, p = 0.0003, pc = 0.034) or controls (51% vs. 18%, p = 0.0002, pc = 0.045) The present data suggest DR4 and DQ8 to be operating jointly as susceptibility factor for the allergy to hevein.
H P Rihs; Z Chen; R Cremer; X Baur
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  49     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-15     Completed Date:  1997-04-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  92-5     Citation Subset:  IM    
Institute for Occupational Medicine (BGFA), Ruhr University Bochum, Germany.
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MeSH Terms
Allergens / immunology*
Antimicrobial Cationic Peptides*
HLA-DQ Antigens / genetics,  immunology*
HLA-DR4 Antigen / genetics,  immunology*
Hypersensitivity / immunology*
Lectins / immunology*
Plant Lectins*
Plant Proteins / immunology*
Reg. No./Substance:
0/Allergens; 0/Antimicrobial Cationic Peptides; 0/HLA-DQ Antigens; 0/HLA-DR4 Antigen; 0/Lectins; 0/Plant Lectins; 0/Plant Proteins; 137295-60-4/hevein

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