| HLA class II antigens DR4 and DQ8 are associated with allergy to hevein, a major allergen of Hevea latex. | |
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MedLine Citation:
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PMID: 9027975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study we investigated the relationship between HLA class II alleles and the IgE-specific immune response to the 4.7 kDa polypeptide hevein of Hevea brasiliensis, a major latex allergen, 51 individuals with immediate-type latex allergy and 90 controls were examined for the polymorphisms in exon 2 of HLA-DRB1, 3, 4, 5 and DQB1 by sequence-specific oligonucleotide probe typing. 35 (69%) out of 51 latex-sensitized subjects showed positive hevein-specific IgE values. Analysis of the HLA data among these 35 subjects revealed increased phenotype frequencies for DR4 (22/35, 63%) and DQ8 (18/35, 51%) when compared with those in the 16 hevein-negative but latex-positive subjects (DR4: 2/16, 13%, p = 0.0009, Pc = 0.047; DQ8: 0/16, p = 0.0003, pc = 0.018) and with healthy controls (DR4: 22/90, 24%, p = 0.00012, pc = 0.013; DQ8: 16/89, 18%, p = 0.0003, pc = 0.036). Finally the DR4-DQ8 haplotype frequency was significantly elevated in hevein-positives when compared with hevein-negatives (51% vs. 0, p = 0.0003, pc = 0.034) or controls (51% vs. 18%, p = 0.0002, pc = 0.045) The present data suggest DR4 and DQ8 to be operating jointly as susceptibility factor for the allergy to hevein. |
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Authors:
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H P Rihs; Z Chen; R Cremer; X Baur |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Tissue antigens Volume: 49 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-04-15 Completed Date: 1997-04-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: DENMARK |
Other Details:
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Languages: eng Pagination: 92-5 Citation Subset: IM |
Affiliation:
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Institute for Occupational Medicine (BGFA), Ruhr University Bochum, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Allergens / immunology* Antimicrobial Cationic Peptides* Female HLA-DQ Antigens / genetics, immunology* HLA-DR4 Antigen / genetics, immunology* Humans Hypersensitivity / immunology* Lectins / immunology* Male Phenotype Plant Lectins* Plant Proteins / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Antimicrobial Cationic Peptides; 0/HLA-DQ Antigens; 0/HLA-DR4 Antigen; 0/Lectins; 0/Plant Lectins; 0/Plant Proteins; 137295-60-4/hevein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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