Document Detail

HLA class II alleles and salivary numbers of mutans streptococci and lactobacilli among young adults in Japan.
MedLine Citation:
PMID:  11737658     Owner:  NLM     Status:  MEDLINE    
To investigate the genetic predisposition toward the accumulation of oral microorganisms, the association between the alleles of HLA-DQA1, -DQB1 and -DRB1 and the salivary numbers of mutans streptococci and lactobacilli were examined in 102 young adults in Japan. HLA-DQA1*0102, DQB1*0604, DRB1*0802, and DRB1*1302 were weakly associated with the numbers of lactobacilli in saliva samples (P<0.05). HLA-DQB1*0601 was associated with the salivary numbers of mutans streptococci (P<0.01). Two HLA class II haplotypes, HLA-[DRB1*0802-DQA1*0301-DQB1*0302] and HLA-[DRB1*1302-DQA1*0102-DQB1*0604], were also weakly associated with the salivary numbers of lactobacilli (P<0.05). These observations suggest that HLA class II alleles may be related to the salivary populations of oral microorganisms, such as mutans streptococci and lactobacilli.
Y Ozawa; J Chiba; S Sakamoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oral microbiology and immunology     Volume:  16     ISSN:  0902-0055     ISO Abbreviation:  Oral Microbiol. Immunol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-02-08     Revised Date:  2010-10-15    
Medline Journal Info:
Nlm Unique ID:  8707451     Medline TA:  Oral Microbiol Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  353-7     Citation Subset:  D    
Department of Preventive Dentistry, Tohoku University School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
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MeSH Terms
Age Factors
Chi-Square Distribution
Colony Count, Microbial
Confidence Intervals
DMF Index
Dental Caries / microbiology
Gene Frequency / genetics
Genetic Predisposition to Disease / genetics
HLA-D Antigens / genetics*
HLA-DQ Antigens / genetics
HLA-DR Antigens / genetics
Haplotypes / genetics
Histocompatibility Antigens Class II / genetics*
Lactobacillus / growth & development*
Odds Ratio
Saliva / microbiology*
Statistics as Topic
Streptococcus mutans / growth & development*
Reg. No./Substance:
0/HLA-D Antigens; 0/HLA-DQ Antigens; 0/HLA-DQA1; 0/HLA-DQB1 antigen; 0/HLA-DR Antigens; 0/Histocompatibility Antigens Class II; 128338-86-3/HLA-DRB1 antigen

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