Document Detail


HLA class II DRB1, DQA1 and DQB1 polymorphisms in the Polish population from Wielkopolska.
MedLine Citation:
PMID:  9234484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HLA DRB1, DQA1 and DQB1 alleles were determined by DNA PCR-SSO typing in a sample of 99 individuals originating from Wielkopolska (midwestern Poland). A high number of alleles (38 DRB1, 8 DQA1 and 14 DQB1) was detected at each locus, many of them presenting notable frequencies in this population. The three HLA loci are thus characterized by very high heterozygosity levels (93% for DRB1, 85% for DQA1, and 88% for DQB1), which confirms the results found for other European populations. A total of 6 DRB1-DQA1-DQB1 haplotypes are detected with an estimated frequency higher than 5%, namely, DRB1*1501-DQA1*0102-DQB1*0602, DRB1*0701-DQA1*0201-DQB1*0201, DRB1*0101-DQA1*0101-DQB1*0501, DRB1*1101-DQA1*0501-DQB1*0301, DRB1*03011-DQA1*0501-DQB1*0201, and DRB1*1301-DQA1*0103-DQB1*0603. A genetic distance analysis between the Polish and other world populations tested for HLA class II indicates that the Wielkopolska community is close to geographically close, rather than linguistically related populations from Europe. More generally, a good agreement between genetics and geography is found for DRB1 and DQB1 polymorphisms in Europe, suggesting that these two loci are highly informative for assessing historical relationships among humans.
Authors:
M Jungerman; A Sanchez-Mazas; P Fichna; R Ivanova; D Charron; J Hors; S Djoulah
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tissue antigens     Volume:  49     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-10-20     Completed Date:  1997-10-20     Revised Date:  2010-10-15    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  624-8     Citation Subset:  IM    
Affiliation:
Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Gene Frequency
HLA-DQ Antigens / genetics*
HLA-DR Antigens / genetics*
Haplotypes
Humans
Poland
Polymorphism, Genetic*
Chemical
Reg. No./Substance:
0/HLA-DQ Antigens; 0/HLA-DQA1; 0/HLA-DQB1 antigen; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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