Document Detail

HLA class II (DR and DQ) antigen associations in idiopathic dilated cardiomyopathy. Validation study and meta-analysis of published HLA association studies.
MedLine Citation:
PMID:  1825038     Owner:  NLM     Status:  MEDLINE    
We previously reported antigen frequency differences for HLA-DR4 and HLA-DRw6 between idiopathic dilated cardiomyopathy (IDC) patients and healthy controls in a pilot study. To confirm these findings, we undertook an independent study with a prospective hypothesis regarding the frequencies of DR4 and DRw6; typing for a second family of class II antigens (HLA-DQ) was included because of the proximity of the DQ loci to the DR loci and the strong linkage disequilibrium between some of the DR and DQ alleles. Comparing a new consecutive series of IDC patients (n = 41) and healthy blood bank controls (n = 53), we confirmed an increase of DR4 antigen frequency in patients (49% versus 21%, p less than 0.005). A trend toward decreased expression of DRw6 among patients was also noted (10% of patients versus 23% of controls). HLA-DQw4 was significantly elevated in patients compared with controls (27% versus 6%, p less than 0.005; relative risk, 6.1; etiologic fraction, 0.22). We identified the combined DR4-DQw4 haplotype in five of 41 Caucasian IDC patients (12%) and none of 53 controls (p less than 0.007). A comparison of specific antigen frequencies between the preliminary and validation studies did not reveal significant differences; therefore, the data from the two studies were examined in combination. For the combined studies, DR4 was elevated (51% versus 27% in controls, p less than 0.001), and DRw6 was decreased (9% versus 24% in controls, p less than 0.01). The relative risk for DR4 was 2.8, and the etiologic fraction was 0.33.(ABSTRACT TRUNCATED AT 250 WORDS)
J F Carlquist; R L Menlove; M B Murray; J B O'Connell; J L Anderson
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  83     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-03-12     Completed Date:  1991-03-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  515-22     Citation Subset:  AIM; IM    
Department of Internal Medicine, University of Utah, LDS Hospital, Salt Lake City 84143.
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MeSH Terms
Cardiomyopathy, Dilated / epidemiology,  genetics*
Gene Frequency
HLA-DQ Antigens / genetics*
HLA-DR Antigens / genetics*
Histocompatibility Testing
Meta-Analysis as Topic
Reproducibility of Results
Risk Factors
Grant Support
S07 RR-05804-09/RR/NCRR NIH HHS
Reg. No./Substance:
0/HLA-DQ Antigens; 0/HLA-DR Antigens
Comment In:
Circulation. 1991 Feb;83(2):704-6   [PMID:  1991387 ]

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