Document Detail


HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia.
MedLine Citation:
PMID:  2234843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A strong association with HLA antigens DR4, DRw53, and Bw54 has previously been reported among Japanese patients with Vogt-Koyanagi-Harada disease (VKH) and sympathetic ophthalmia (SO). In the United States, no firm association between HLA-A or -B loci and VKH has been found previously; testing for HLA-DR loci has not been performed to date. The authors performed HLA typing of 23 American patients with VKH and 8 patients with SO. When VKH patients were compared with racially matched controls without disease and patients with other types of uveitis, strong associations with HLA-DR4 and HLA-DRw53 were found. The strongest associations observed in this sample were with HLA-DQw3, an antigen which is in positive linkage disequilibrium with DR4, and with the HLA-DR4/DQw3 haplotype. The small number of patients with SO precluded statistical analysis; however, similar HLA associations were noted. The patients also were questioned regarding their ancestry. The anecdotal association of VKH with American Indian ancestry was confirmed. It appears that the ethnoracial association may be explained by HLA type. One possible explanation for identical HLA associations in two diseases with different precipitating events yet similar ocular manifestations is development of an altered immune response to exogenous microbial antigen with subsequent autoimmunity. Further definition of the genetic susceptibility to VKH and SO may help define the pathophysiology of both diseases and allow the prediction of which patients are at increased risk for SO.
Authors:
J L Davis; K K Mittal; V Freidlin; S R Mellow; D C Optican; A G Palestine; R B Nussenblatt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmology     Volume:  97     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-12-05     Completed Date:  1990-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1137-42     Citation Subset:  IM    
Affiliation:
Laboratory of Immunology, National Eye Institute, Bethesda.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group / genetics
European Continental Ancestry Group / genetics
HLA Antigens / blood*
Histocompatibility Testing
Humans
Indians, North American / genetics
Odds Ratio
Ophthalmia, Sympathetic / ethnology,  genetics,  immunology*
Prevalence
Questionnaires
United States
Uveomeningoencephalitic Syndrome / ethnology,  genetics,  immunology*
Chemical
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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