| HLA association with nasopharyngeal carcinoma in southern Tunisia. | |
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MedLine Citation:
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PMID: 19714482 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to study the association of HLA-A, -B and/or DRB1, DQB1 and the nasopharyngeal carcinoma (NPC), 141 patients affected with NPC were typed for the HLA class I by serology method of microlymphocytotoxicity. Among these patients 101 were genotyped for HLA class II system by the PCR-SSP technique. HLA typing results were compared to those of 116 controls. We found that the HLA-A31 and -A33 antigens were significantly more expressed in patients than in the controls (P = 0.016 and 0.010, respectively) and the HLA-A19 antigen, was significantly more frequent in patients when compared to the controls (P = 0.007). The HLA-DRB1*03 and DRB1*13 alleles were significantly more frequent in patients as compared to the controls. The DRB1*01 allele was expressed with a frequency of 20.69% in the controls whereas it was only detected in 3.96% of the NPC patients. Furthermore, the DQB1*05 allele was expressed at a frequency which was significantly less important in affected patient (P = 0.03), whereas, the DQB1*02 allele was more frequent in patients (P = 0.643 x 10(-4)). Thus our study revealed a significant increase of HLA-A31, A33, A19, B16, B53 and DRB1*03, DRB1*13 and DQB1*02 alleles in our patients. These markers could play a predisposing role in the development of NPC. In contrast, a decrease of HLA-B14, -B35 and DRB1*01 and DQB1*05 alleles was found suggesting a likely protective effect. |
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Authors:
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Hafedh Makni; Jamel Daoud; Hanène Ben Salah; Nedia Mahfoudh; Olfa Haddar; Héla Karray; Tahya Boudawara; Abdelmonême Ghorbel; Abdelmajid Khabir; Mounir Frikha |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-28 |
Journal Detail:
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Title: Molecular biology reports Volume: 37 ISSN: 1573-4978 ISO Abbreviation: Mol. Biol. Rep. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0403234 Medline TA: Mol Biol Rep Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2533-9 Citation Subset: IM |
Affiliation:
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Immunology Laboratory, University Hospital Sfax, Sfax, Tunisia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Distribution Aged Alleles Case-Control Studies Child Female Gene Frequency / genetics Genetic Predisposition to Disease* HLA Antigens / genetics*, immunology* Haplotypes / genetics Histocompatibility Testing Humans Male Middle Aged Nasopharyngeal Neoplasms / genetics*, immunology* Phenotype Tunisia Young Adult |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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