Document Detail

HLA association with nasopharyngeal carcinoma in southern Tunisia.
MedLine Citation:
PMID:  19714482     Owner:  NLM     Status:  MEDLINE    
In order to study the association of HLA-A, -B and/or DRB1, DQB1 and the nasopharyngeal carcinoma (NPC), 141 patients affected with NPC were typed for the HLA class I by serology method of microlymphocytotoxicity. Among these patients 101 were genotyped for HLA class II system by the PCR-SSP technique. HLA typing results were compared to those of 116 controls. We found that the HLA-A31 and -A33 antigens were significantly more expressed in patients than in the controls (P = 0.016 and 0.010, respectively) and the HLA-A19 antigen, was significantly more frequent in patients when compared to the controls (P = 0.007). The HLA-DRB1*03 and DRB1*13 alleles were significantly more frequent in patients as compared to the controls. The DRB1*01 allele was expressed with a frequency of 20.69% in the controls whereas it was only detected in 3.96% of the NPC patients. Furthermore, the DQB1*05 allele was expressed at a frequency which was significantly less important in affected patient (P = 0.03), whereas, the DQB1*02 allele was more frequent in patients (P = 0.643 x 10(-4)). Thus our study revealed a significant increase of HLA-A31, A33, A19, B16, B53 and DRB1*03, DRB1*13 and DQB1*02 alleles in our patients. These markers could play a predisposing role in the development of NPC. In contrast, a decrease of HLA-B14, -B35 and DRB1*01 and DQB1*05 alleles was found suggesting a likely protective effect.
Hafedh Makni; Jamel Daoud; Hanène Ben Salah; Nedia Mahfoudh; Olfa Haddar; Héla Karray; Tahya Boudawara; Abdelmonême Ghorbel; Abdelmajid Khabir; Mounir Frikha
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-28
Journal Detail:
Title:  Molecular biology reports     Volume:  37     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2533-9     Citation Subset:  IM    
Immunology Laboratory, University Hospital Sfax, Sfax, Tunisia.
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MeSH Terms
Age Distribution
Case-Control Studies
Gene Frequency / genetics
Genetic Predisposition to Disease*
HLA Antigens / genetics*,  immunology*
Haplotypes / genetics
Histocompatibility Testing
Middle Aged
Nasopharyngeal Neoplasms / genetics*,  immunology*
Young Adult
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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