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HLA-DRB1*0101/*0405 is associated with susceptibility to Anti-MDA5 antibody-positive dermatomyositis in the Japanese population.
MedLine Citation:
PMID:  22886382     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE.: The complication of interstitial lung disease (ILD) is associated with the anti-aminoacyl tRNA synthetase antibody (ARS ab) or the anti-MDA5 antibody (MDA5 ab) in polymyositis (PM)/dermatomyositis (DM). Anti-MDA5 ab is associated with clinically amyopathic DM and fatal outcome due to rapidly progressive ILD in Asia. The association between genetic factors and anti-MDA5 ab-positive DM has remained unclear. We investigated the HLA-DRB1 genotype in anti- MDA5 ab-positive DM. METHODS.: We compared the genetic differences among 17 patients with anti-MDA5 ab-positive DM, 33 patients with anti-ARS ab-positive PM/DM, 33 PM/DM patients without anti-ARS ab or ILD and 265 healthy controls (HCs). RESULTS.: The frequencies of HLA-DRB1*0101 and DRB1*0405 were 29% and 71% in anti-MDA5 ab-positive DM, respectively, which were higher than the frequencies in HCs (10% and 25%, respectively). Among 17 patients with anti-MDA5 ab-positive DM, 16 (94%) patients harbored either the DRB1*0101 or DRB1*0405 allele. The frequency of the DRB1*0101 or 0405 allele was significantly higher in anti-MDA5 ab-positive DM patients compared with PM/DM patients without anti-ARS ab or ILD (P = 1.1e-05, odds ratio 42.7, confidence interval [CI] 4.9-370.2) or anti-ARS ab-positive PM/DM patients (P = 4.5e-03, odds ratio 13.3, CI 1.6-112.6). CONCLUSION.: HLA-DRB1*0101/*0405 is associated with susceptibility to anti-MDA5 ab-positive DM in the Japanese population. © 2012 American College of Rheumatology.
Authors:
Takahisa Gono; Yasushi Kawaguchi; Masataka Kuwana; Tomoko Sugiura; Takefumi Furuya; Kae Takagi; Hisae Ichida; Yasuhiro Katsumata; Masanori Hanaoka; Yuko Ota; Hisashi Yamanaka
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-8
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  -     ISSN:  1529-0131     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
Affiliation:
Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
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