Document Detail


HLA-antigens and tuberculosis in the Egyptian population.
MedLine Citation:
PMID:  3872495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral blood lymphocytes from 42 unrelated Egyptian patients with tuberculosis and 156 healthy persons were HLA phenotyped for the A,B and DR loci using the NIH lymphocytotoxicity tests. Statistical analysis of the results showed that A2 and B5 had significantly increased frequencies among patients with tuberculosis compared with the controls. Patients with A2 had more severe disease than did patients without A2 and the number with B5 antigen was less than those without the antigen. This observation suggests that A2 and B5 may influence susceptibility to tuberculosis, but not the course of the disease. Furthermore, a linkage disequilibrium was found between A2 and B5 antigen among tuberculous patients, but their association bore no relation to the severity of the disease.
Authors:
M Hafez; S el-Salab; F el-Shennawy; M R Bassiony
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tubercle     Volume:  66     ISSN:  0041-3879     ISO Abbreviation:  Tubercle     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-05-09     Completed Date:  1985-05-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1273730     Medline TA:  Tubercle     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Egypt
Female
HLA Antigens / analysis*
HLA-A2 Antigen
HLA-B Antigens*
Humans
Infant
Linkage (Genetics)
Male
Phenotype
Risk
Tuberculosis, Pulmonary / genetics,  immunology*
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/HLA-A2 Antigen; 0/HLA-B Antigens; 0/HLA-B5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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