Document Detail

The HLA antigens and leprosy in Thailand.
MedLine Citation:
PMID:  87028     Owner:  NLM     Status:  MEDLINE    
HLA-A and -B locus antigens were determined in 170 unrelated patients with leprosy and 100 healthy controls. There were no statistically significant deviations from expected antigen distribution in patients with any of the various forms of leprosy, though the number of patients studied is relatively small. There were some interesting trends, particularly a possible decrease in the number of tuberculoid patients with A9, and an increase in the proportions of lepromatous patients with B18 and B40. Limited evidence of a genetically controlled pre-disposition to the clinical manifestations of leprosy suggests that further studies with extended typing should be carried out on the HLA haplotype segregation in informative leprosy families. These should provide a clearer indication of the relevance of the HLA (including DR) and possibly of other non-HLA loci to the possible mechanism(s) of disease susceptibility.
P Chiewsilp; S Athkambhira; T Chirachariyavej; N Bhamarapravati; C Entwistle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  13     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-07-25     Completed Date:  1979-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  186-8     Citation Subset:  IM    
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MeSH Terms
Chromosome Mapping
HLA Antigens* / analysis
Leprosy / genetics,  immunology*
Middle Aged
Reg. No./Substance:
0/Epitopes; 0/HLA Antigens

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