Document Detail

HLA antigens in malignant melanoma patients.
MedLine Citation:
PMID:  6769187     Owner:  NLM     Status:  MEDLINE    
One hundred and forty melanoma patients, divided in 2 groups, i.e., patients with clinical evidence of melanoma and patients with no clinical evidence of melanoma, were typed for HLA-A, -B and -C antigens and compared with 340 to 905 (according to each HLA antigen examined) healthy adult blood donors. Overall, a highly significant increase in HLA-B40 antigen (p = 5.6 x 10(-7)) and a decrease in HLA-BW35 (p = 1.6 x 10(-4)) was observed. No relevant difference was found between the 2 groups. Moreover, an unexpected excess of HLA blanks was observed at both A and B loci in the first group (p = 1.3 x 10(-2) and p = 3.3 x 10(-6), respectively) and only at the B locus in the second (p = 1.2 x 10(-2)), when the patients were compared to 288 healthy individuals HLA typed at the same time and with the same HLA antisera as the patients. The increase in HLA blanks in melanoma patients deserves further investigation to ascertain whether it may be due to the tumor not yet surgically removed or may be referred to technical pitfalls.
G Pellegris; M T Illeni; M Vaglini; D Rovini; N Cascinelli; C Masserini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tumori     Volume:  66     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-07-22     Completed Date:  1980-07-22     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  51-8     Citation Subset:  IM    
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MeSH Terms
Antigens, Neoplasm
Chromosome Mapping
Genes, MHC Class II*
HLA Antigens / genetics*
Histocompatibility Testing
Lymphocytes / ultrastructure
Melanoma / genetics,  immunology*
Middle Aged
Reg. No./Substance:
0/Antigens, Neoplasm; 0/HLA Antigens

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