Document Detail

HLA antigens in black South African children with rheumatic heart disease.
MedLine Citation:
PMID:  6186186     Owner:  NLM     Status:  MEDLINE    
The high incidence of rheumatic heart disease (RHD) in black South African children has been attributed mainly to poor socio-economic status and over-crowding. In order to elucidate whether other factors, in particular genetic, were responsible, the HLA-status of 61 black children with rheumatic heart disease was compared with that of 1165 normal controls. Overall, no differences were found, except a higher incidence of HLA-B25 and BW51 in the group with rheumatic heart disease, when the difference was not of statistical significance. Moreover, when the patients were considered in two groups, viz. (a) a "surgical" group which required cardiac surgery and (b) a "non-surgical" group in which cardiac failure was absent or could be easily controlled by medical therapy, the difference between the two groups was also not of statistical significance, though there was a higher incidence of HLA-A10 (which includes HLA-A25 and A26) in the "non-surgical" group. These data appear to agree with the results of other studies which found no significant association between HLA-status and RHD.
I E Haffejee; M G Hammond; A Moosa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  2     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1983-03-24     Completed Date:  1983-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  IM    
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MeSH Terms
African Continental Ancestry Group
HLA Antigens / analysis*
Rheumatic Heart Disease / immunology*,  pathology
South Africa
Reg. No./Substance:
0/HLA Antigens

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