Document Detail


HLA antigens in Spanish type 1 diabetic population. Correlations with clinical, biological and autoimmune markers.
MedLine Citation:
PMID:  2075784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The HLA haplotype and its relationships with clinical, biological and immunological parameters were analyzed in a group of 87 Spanish type 1 diabetic patients at the clinical onset of the disease. The frequency of HLA-B18, DR3 and DR4 antigens was significantly increased whereas DR2, DR5 and DR7 were decreased in comparison with 189 healthy unrelated controls without family history of diabetes. DR3 showed a maximum relative risk for diabetes (5.5) whereas DR4 had a lower one (4.0). HLA-DR4 patients were younger at the time of diagnosis than DR4 negative (16.7 vs 21.4 years). We found no statistically significant relationship between HLA antigens and the other variables studied including the presence of islet cell antibodies, complement fixing islet cell antibodies, insulin autoantibodies, organ-specific antibodies, fasting and maximal glucagon stimulated C-peptide levels, initial glycemia and glycosylated hemoglobin.
Authors:
A Goday; E Motaña; G Ercilla; J Fernandez; R Gomis; E Vilardell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta diabetologica latina     Volume:  27     ISSN:  0001-5563     ISO Abbreviation:  Acta Diabetol Lat     Publication Date:    1990 Jul-Sep
Date Detail:
Created Date:  1991-04-16     Completed Date:  1991-04-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0123567     Medline TA:  Acta Diabetol Lat     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  IM    
Affiliation:
Servei d'Endocrinologia i Diabetis, Hospital Clinic, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoantibodies / immunology
Autoimmunity
Diabetes Mellitus, Type 1 / immunology*
Female
HLA Antigens / immunology*
HLA-B Antigens / immunology
HLA-DR3 Antigen / immunology
HLA-DR4 Antigen / immunology
Humans
Insulin Antibodies / immunology
Islets of Langerhans / immunology
Male
Spain
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/HLA Antigens; 0/HLA-B Antigens; 0/HLA-B18; 0/HLA-DR3 Antigen; 0/HLA-DR4 Antigen; 0/Insulin Antibodies

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