Document Detail

HLA antigens in Spanish type 1 diabetic population. Correlations with clinical, biological and autoimmune markers.
MedLine Citation:
PMID:  2075784     Owner:  NLM     Status:  MEDLINE    
The HLA haplotype and its relationships with clinical, biological and immunological parameters were analyzed in a group of 87 Spanish type 1 diabetic patients at the clinical onset of the disease. The frequency of HLA-B18, DR3 and DR4 antigens was significantly increased whereas DR2, DR5 and DR7 were decreased in comparison with 189 healthy unrelated controls without family history of diabetes. DR3 showed a maximum relative risk for diabetes (5.5) whereas DR4 had a lower one (4.0). HLA-DR4 patients were younger at the time of diagnosis than DR4 negative (16.7 vs 21.4 years). We found no statistically significant relationship between HLA antigens and the other variables studied including the presence of islet cell antibodies, complement fixing islet cell antibodies, insulin autoantibodies, organ-specific antibodies, fasting and maximal glucagon stimulated C-peptide levels, initial glycemia and glycosylated hemoglobin.
A Goday; E Motaña; G Ercilla; J Fernandez; R Gomis; E Vilardell
Related Documents :
8773324 - Distribution of hla-dqa1 and -dqb1 alleles and dqa1-dqb1 genotypes among senegalese pat...
7051714 - Increase of hla haplotype a9-bw16 in familial insulin-dependent diabetes mellitus in no...
15991024 - Diabetes-associated hla genotypes affect birthweight in the general population.
12731574 - Hla-dw antigens in unrelated juvenile, insulin-dependent diabetics.
23761104 - Disordered control of intestinal sweet taste receptor expression and glucose absorption...
23487174 - Lx4211 increases serum glp-1 and pyy levels by reducing sglt-1-mediated absorption of i...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta diabetologica latina     Volume:  27     ISSN:  0001-5563     ISO Abbreviation:  Acta Diabetol Lat     Publication Date:    1990 Jul-Sep
Date Detail:
Created Date:  1991-04-16     Completed Date:  1991-04-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0123567     Medline TA:  Acta Diabetol Lat     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  IM    
Servei d'Endocrinologia i Diabetis, Hospital Clinic, Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Autoantibodies / immunology
Diabetes Mellitus, Type 1 / immunology*
HLA Antigens / immunology*
HLA-B Antigens / immunology
HLA-DR3 Antigen / immunology
HLA-DR4 Antigen / immunology
Insulin Antibodies / immunology
Islets of Langerhans / immunology
Reg. No./Substance:
0/Autoantibodies; 0/HLA Antigens; 0/HLA-B Antigens; 0/HLA-B18; 0/HLA-DR3 Antigen; 0/HLA-DR4 Antigen; 0/Insulin Antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Quantitative and qualitative differences in basal and glucose- and arginine-stimulated insulin secre...
Next Document:  HLA gene and phenotype data of 60 insulin-dependent diabetic patients from north-eastern Italy. A ne...