| HLA antigens in Asian Indian patients with Graves' disease. | |
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MedLine Citation:
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PMID: 2401095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study of 57 Asian Indian patients with Graves' disease revealed a significant increase in the frequency of HLA-DQW2 (61.4%) as compared to the control population (22.6%) giving a relative risk of 5.4. Less prominent but statistically significant increase in the frequency of HLA-A10 (29.8% patients as opposed to 10.5% controls) and HLA-B8 (28.1% patients as opposed to 8.7% controls) was also observed. Further, patients carrying the phenotypes HLA-A10 and HLA-B8 were more prone to develop the disease at a younger age. Two HLA haplotypes, namely A10-B8 and B8-DR3, were found in significant linkage disequilibrium in our patients with Graves' disease. Patients carrying these haplotypes also had a tendency to develop the disease at an earlier age. |
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Authors:
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N Tandon; N K Mehra; V Taneja; M C Vaidya; N Kochupillai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical endocrinology Volume: 33 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-10-26 Completed Date: 1990-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 21-6 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, All-India Institute of Medical Sciences, New Delhi. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Female Graves Disease / ethnology, immunology* HLA Antigens / analysis* HLA-A Antigens / analysis HLA-B Antigens / analysis HLA-DQ Antigens / analysis Haplotypes / immunology Humans India Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-DQ Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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