Document Detail

HLA antigens in Asian Indian patients with Graves' disease.
MedLine Citation:
PMID:  2401095     Owner:  NLM     Status:  MEDLINE    
A study of 57 Asian Indian patients with Graves' disease revealed a significant increase in the frequency of HLA-DQW2 (61.4%) as compared to the control population (22.6%) giving a relative risk of 5.4. Less prominent but statistically significant increase in the frequency of HLA-A10 (29.8% patients as opposed to 10.5% controls) and HLA-B8 (28.1% patients as opposed to 8.7% controls) was also observed. Further, patients carrying the phenotypes HLA-A10 and HLA-B8 were more prone to develop the disease at a younger age. Two HLA haplotypes, namely A10-B8 and B8-DR3, were found in significant linkage disequilibrium in our patients with Graves' disease. Patients carrying these haplotypes also had a tendency to develop the disease at an earlier age.
N Tandon; N K Mehra; V Taneja; M C Vaidya; N Kochupillai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical endocrinology     Volume:  33     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-10-26     Completed Date:  1990-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  21-6     Citation Subset:  IM    
Department of Endocrinology, All-India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Age Factors
Graves Disease / ethnology,  immunology*
HLA Antigens / analysis*
HLA-A Antigens / analysis
HLA-B Antigens / analysis
HLA-DQ Antigens / analysis
Haplotypes / immunology
Middle Aged
Reg. No./Substance:
0/HLA Antigens; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-DQ Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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